Cargando…

WNT5B in Physiology and Disease

WNT5B, a member of the WNT family of proteins that is closely related to WNT5A, is required for cell migration, cell proliferation, or cell differentiation in many cell types. WNT5B signals through the non-canonical β-catenin-independent signaling pathway and often functions as an antagonist of cano...

Descripción completa

Detalles Bibliográficos
Autores principales: Suthon, Sarocha, Perkins, Rachel S., Bryja, Vitezslav, Miranda-Carboni, Gustavo A., Krum, Susan A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129536/
https://www.ncbi.nlm.nih.gov/pubmed/34017835
http://dx.doi.org/10.3389/fcell.2021.667581
_version_ 1783694312550170624
author Suthon, Sarocha
Perkins, Rachel S.
Bryja, Vitezslav
Miranda-Carboni, Gustavo A.
Krum, Susan A.
author_facet Suthon, Sarocha
Perkins, Rachel S.
Bryja, Vitezslav
Miranda-Carboni, Gustavo A.
Krum, Susan A.
author_sort Suthon, Sarocha
collection PubMed
description WNT5B, a member of the WNT family of proteins that is closely related to WNT5A, is required for cell migration, cell proliferation, or cell differentiation in many cell types. WNT5B signals through the non-canonical β-catenin-independent signaling pathway and often functions as an antagonist of canonical WNT signaling. Although WNT5B has a high amino acid identity with WNT5A and is often assumed to have similar activities, WNT5B often exhibits unique expression patterns and functions. Here, we describe the distinct effects and mechanisms of WNT5B on development, bone, adipose tissue, cardiac tissue, the nervous system, the mammary gland, the lung and hematopoietic cells, compared to WNT5A. We also highlight aberrances in non-canonical WNT5B signaling contributing to diseases such as osteoarthritis, osteoporosis, obesity, type 2 diabetes mellitus, neuropathology, and chronic diseases associated with aging, as well as various cancers.
format Online
Article
Text
id pubmed-8129536
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-81295362021-05-19 WNT5B in Physiology and Disease Suthon, Sarocha Perkins, Rachel S. Bryja, Vitezslav Miranda-Carboni, Gustavo A. Krum, Susan A. Front Cell Dev Biol Cell and Developmental Biology WNT5B, a member of the WNT family of proteins that is closely related to WNT5A, is required for cell migration, cell proliferation, or cell differentiation in many cell types. WNT5B signals through the non-canonical β-catenin-independent signaling pathway and often functions as an antagonist of canonical WNT signaling. Although WNT5B has a high amino acid identity with WNT5A and is often assumed to have similar activities, WNT5B often exhibits unique expression patterns and functions. Here, we describe the distinct effects and mechanisms of WNT5B on development, bone, adipose tissue, cardiac tissue, the nervous system, the mammary gland, the lung and hematopoietic cells, compared to WNT5A. We also highlight aberrances in non-canonical WNT5B signaling contributing to diseases such as osteoarthritis, osteoporosis, obesity, type 2 diabetes mellitus, neuropathology, and chronic diseases associated with aging, as well as various cancers. Frontiers Media S.A. 2021-05-04 /pmc/articles/PMC8129536/ /pubmed/34017835 http://dx.doi.org/10.3389/fcell.2021.667581 Text en Copyright © 2021 Suthon, Perkins, Bryja, Miranda-Carboni and Krum. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Suthon, Sarocha
Perkins, Rachel S.
Bryja, Vitezslav
Miranda-Carboni, Gustavo A.
Krum, Susan A.
WNT5B in Physiology and Disease
title WNT5B in Physiology and Disease
title_full WNT5B in Physiology and Disease
title_fullStr WNT5B in Physiology and Disease
title_full_unstemmed WNT5B in Physiology and Disease
title_short WNT5B in Physiology and Disease
title_sort wnt5b in physiology and disease
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129536/
https://www.ncbi.nlm.nih.gov/pubmed/34017835
http://dx.doi.org/10.3389/fcell.2021.667581
work_keys_str_mv AT suthonsarocha wnt5binphysiologyanddisease
AT perkinsrachels wnt5binphysiologyanddisease
AT bryjavitezslav wnt5binphysiologyanddisease
AT mirandacarbonigustavoa wnt5binphysiologyanddisease
AT krumsusana wnt5binphysiologyanddisease