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WNT5B in Physiology and Disease
WNT5B, a member of the WNT family of proteins that is closely related to WNT5A, is required for cell migration, cell proliferation, or cell differentiation in many cell types. WNT5B signals through the non-canonical β-catenin-independent signaling pathway and often functions as an antagonist of cano...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129536/ https://www.ncbi.nlm.nih.gov/pubmed/34017835 http://dx.doi.org/10.3389/fcell.2021.667581 |
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author | Suthon, Sarocha Perkins, Rachel S. Bryja, Vitezslav Miranda-Carboni, Gustavo A. Krum, Susan A. |
author_facet | Suthon, Sarocha Perkins, Rachel S. Bryja, Vitezslav Miranda-Carboni, Gustavo A. Krum, Susan A. |
author_sort | Suthon, Sarocha |
collection | PubMed |
description | WNT5B, a member of the WNT family of proteins that is closely related to WNT5A, is required for cell migration, cell proliferation, or cell differentiation in many cell types. WNT5B signals through the non-canonical β-catenin-independent signaling pathway and often functions as an antagonist of canonical WNT signaling. Although WNT5B has a high amino acid identity with WNT5A and is often assumed to have similar activities, WNT5B often exhibits unique expression patterns and functions. Here, we describe the distinct effects and mechanisms of WNT5B on development, bone, adipose tissue, cardiac tissue, the nervous system, the mammary gland, the lung and hematopoietic cells, compared to WNT5A. We also highlight aberrances in non-canonical WNT5B signaling contributing to diseases such as osteoarthritis, osteoporosis, obesity, type 2 diabetes mellitus, neuropathology, and chronic diseases associated with aging, as well as various cancers. |
format | Online Article Text |
id | pubmed-8129536 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81295362021-05-19 WNT5B in Physiology and Disease Suthon, Sarocha Perkins, Rachel S. Bryja, Vitezslav Miranda-Carboni, Gustavo A. Krum, Susan A. Front Cell Dev Biol Cell and Developmental Biology WNT5B, a member of the WNT family of proteins that is closely related to WNT5A, is required for cell migration, cell proliferation, or cell differentiation in many cell types. WNT5B signals through the non-canonical β-catenin-independent signaling pathway and often functions as an antagonist of canonical WNT signaling. Although WNT5B has a high amino acid identity with WNT5A and is often assumed to have similar activities, WNT5B often exhibits unique expression patterns and functions. Here, we describe the distinct effects and mechanisms of WNT5B on development, bone, adipose tissue, cardiac tissue, the nervous system, the mammary gland, the lung and hematopoietic cells, compared to WNT5A. We also highlight aberrances in non-canonical WNT5B signaling contributing to diseases such as osteoarthritis, osteoporosis, obesity, type 2 diabetes mellitus, neuropathology, and chronic diseases associated with aging, as well as various cancers. Frontiers Media S.A. 2021-05-04 /pmc/articles/PMC8129536/ /pubmed/34017835 http://dx.doi.org/10.3389/fcell.2021.667581 Text en Copyright © 2021 Suthon, Perkins, Bryja, Miranda-Carboni and Krum. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Suthon, Sarocha Perkins, Rachel S. Bryja, Vitezslav Miranda-Carboni, Gustavo A. Krum, Susan A. WNT5B in Physiology and Disease |
title | WNT5B in Physiology and Disease |
title_full | WNT5B in Physiology and Disease |
title_fullStr | WNT5B in Physiology and Disease |
title_full_unstemmed | WNT5B in Physiology and Disease |
title_short | WNT5B in Physiology and Disease |
title_sort | wnt5b in physiology and disease |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129536/ https://www.ncbi.nlm.nih.gov/pubmed/34017835 http://dx.doi.org/10.3389/fcell.2021.667581 |
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