Cargando…

Comprehensive PBPK model to predict drug interaction potential of Zanubrutinib as a victim or perpetrator

A physiologically based pharmacokinetic (PBPK) model was developed to evaluate and predict (1) the effect of concomitant cytochrome P450 3A (CYP3A) inhibitors or inducers on the exposures of zanubrutinib, (2) the effect of zanubrutinib on the exposures of CYP3A4, CYP2C8, and CYP2B6 substrates, and (...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Kun, Yao, Xueting, Zhang, Miao, Liu, Dongyang, Gao, Yuying, Sahasranaman, Srikumar, Ou, Ying C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129716/ https://www.ncbi.nlm.nih.gov/pubmed/33687157 http://dx.doi.org/10.1002/psp4.12605

Ejemplares similares

Population Pharmacokinetic Analysis of the BTK Inhibitor Zanubrutinib in Healthy Volunteers and Patients With B‐Cell Malignancies
por: Ou, Ying C., et al.
Publicado: (2021)

In vitro investigations into the roles of CYP450 enzymes and drug transporters in the drug interactions of zanubrutinib, a covalent Bruton's tyrosine kinase inhibitor
por: Zhang, Heather, et al.
Publicado: (2021)

Evaluation of drug interaction potential of zanubrutinib with cocktail probes representative of CYP3A4, CYP2C9, CYP2C19, P‐gp and BCRP
por: Ou, Ying C., et al.
Publicado: (2021)

Effect of rifampin and itraconazole on the pharmacokinetics of zanubrutinib (a Bruton's tyrosine kinase inhibitor) in Asian and non-Asian healthy subjects
por: Mu, Song, et al.
Publicado: (2019)

Tiered approach to evaluate the CYP3A victim and perpetrator drug–drug interaction potential for vonoprazan using PBPK modeling and clinical data to inform labeling
por: Mulford, Darcy J., et al.
Publicado: (2023)

A general pharmacodynamic interaction model identifies perpetrators and victims in drug interactions
por: Wicha, Sebastian G., et al.
Publicado: (2017)

Cybercrime: Victimization, Perpetration, and Techniques
por: Hawdon, James
Publicado: (2021)

Epilepsy and the gut: Perpetrator or victim?
por: Al-Beltagi, Mohammed, et al.
Publicado: (2022)

Victimization and Perpetration Experiences of Adults With Autism
por: Weiss, Jonathan A., et al.
Publicado: (2018)

Intimate partner homicide: victims and the dynamics of victim – perpetrator relationship
por: Matias, Andreia, et al.
Publicado: (2021)

PBPK modeling to predict drug‐drug interactions of ivosidenib as a perpetrator in cancer patients and qualification of the Simcyp platform for CYP3A4 induction
por: Bolleddula, Jayaprakasam, et al.
Publicado: (2021)

Development of a PBPK model to quantitatively understand absorption and disposition mechanism and support future clinical trials for PB‐201
por: Zhang, Miao, et al.
Publicado: (2023)

Islatravir Is Not Expected to Be a Victim or Perpetrator of Drug-Drug Interactions via Major Drug-Metabolizing Enzymes or Transporters
por: Bleasby, Kelly, et al.
Publicado: (2021)

Bullying among adolescents: are the victims also perpetrators?
por: Reisen, Andressa, et al.
Publicado: (2019)

The importance of risk factors for bullying perpetration and victimization()()
por: Farrington, David P.
Publicado: (2020)

No QTc Prolongation With Zanubrutinib: Results of Concentration‐QTc Analysis From a Thorough QT Study in Healthy Subjects
por: Mu, Song, et al.
Publicado: (2020)

Zanubrutinib in lymphoproliferative disorders: a comprehensive review
por: Muñoz, Javier, et al.
Publicado: (2022)

Victims and/or perpetrators? Towards an interdisciplinary dialogue on child soldiers
por: Derluyn, Ilse, et al.
Publicado: (2015)

Intimate partner violence victimization and perpetration as precursors to suicide
por: Kafka, Julie M., et al.
Publicado: (2022)

Perpetrators and victims of cyberbullying among youth with conduct disorder
por: Baumann, Sarah, et al.
Publicado: (2022)

Bullying victimization and perpetration: some answers and more questions()
por: Voisin, Dexter R., et al.
Publicado: (2023)

Development of a physiologically based pharmacokinetic (PBPK) population model for Chinese elderly subjects
por: Cui, Cheng, et al.
Publicado: (2021)

Bullying and Cyberbullying Perpetration and Victimization: Prospective Within-Person Associations
por: Camacho, Antonio, et al.
Publicado: (2022)

Serious Violence Victimization and Perpetration among Youth Living in the Slums of Kampala, Uganda
por: Swahn, Monica H, et al.
Publicado: (2012)

Clinical assessment of gepotidacin (GSK2140944) as a victim and perpetrator of drug–drug interactions via CYP3A metabolism and transporters
por: Barth, Aline, et al.
Publicado: (2023)

Sex Differences in Traditional School Bullying Perpetration and Victimization among Adolescents: A Chain-Mediating Effect
por: Yang, Minqi, et al.
Publicado: (2022)

Zanubrutinib in Mantle Cell Lymphoma Management: A Comprehensive Review
por: Alsuhebany, Nada, et al.
Publicado: (2023)

Stepping into Perpetrators’ Shoes: How Ingroup Transgressions and Victimization Shape Support for Retributive Justice through Perspective-Taking With Perpetrators
por: Li, Mengyao, et al.
Publicado: (2019)

Perpetrator as a Potential Victim. Does Threatened Retaliation from the Victim Reduce Obedience towards Authority?
por: Grzyb, Tomasz, et al.
Publicado: (2017)

The trafficking of women and girls in Taiwan: characteristics of victims, perpetrators, and forms of exploitation
por: Huang, Lanying
Publicado: (2017)

Disparities in Perpetrators, Locations, and Reports of Victimization for Sexual and Gender Minority Adolescents
por: Kaufman, Tessa M. L., et al.
Publicado: (2022)

Differences and Similarities between Perpetrators of Ethnic and Non-Ethnicity-Based Victimization
por: Bayram Özdemir, Sevgi, et al.
Publicado: (2020)

NSAIDs in patients with viral infections, including Covid-19: Victims or perpetrators?
por: Capuano, Annalisa, et al.
Publicado: (2020)

Victims and Perpetrators of Child Sexual Abuse: Abusive Contact and Penetration Experiences
por: Ferragut, Marta, et al.
Publicado: (2021)

Lifetime Prevalence of Victimization and Perpetration as Related to Men’s Health: Clinical Insights
por: Leiding, Delia, et al.
Publicado: (2022)

The relationship between cyberbullying victimization and cyberbullying perpetration: The role of social responsibility
por: Zhan, Jun, et al.
Publicado: (2022)

Modern Rape Myths: Justifying Victim and Perpetrator Blame in Sexual Violence
por: Murray, Carol, et al.
Publicado: (2023)

The Trinidad and Tobago Covid-19 Domestic Violence Victimization and Perpetration Study
por: Wallace, Wendell C., et al.
Publicado: (2022)

The Role of Alexithymia and Impulsivity in Male Victims and Perpetrators of Intimate Partner Violence
por: Mannarini, Stefania, et al.
Publicado: (2023)

Who required the counselling to stop intimate partner violence, victim or perpetrators?
por: Mukhida, Sahjid S., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_o4g73uevkubiv98vg3g8jas4m9