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Population pharmacokinetic modeling and simulation to support qualification of pyridoxic acid as endogenous biomarker of OAT1/3 renal transporters
Renal clearance of many drugs is mediated by renal organic anion transporters OAT1/3 and inhibition of these transporters may lead to drug‐drug interactions (DDIs). Pyridoxic acid (PDA) and homovanillic acid (HVA) were indicated as potential biomarkers of OAT1/3. The objective of this study was to d...
Autores principales: | Ahmad, Amais, Ogungbenro, Kayode, Kunze, Annett, Jacobs, Frank, Snoeys, Jan, Rostami‐Hodjegan, Amin, Galetin, Aleksandra |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129719/ https://www.ncbi.nlm.nih.gov/pubmed/33704919 http://dx.doi.org/10.1002/psp4.12610 |
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