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The zinc-binding motif of TRPM7 acts as an oxidative stress sensor to regulate its channel activity
The activity of the TRPM7 channel is negatively regulated by intracellular Mg(2+). We previously reported that oxidative stress enhances the inhibition of TRPM7 by intracellular Mg(2+). Here, we aimed to clarify the mechanism underlying TRPM7 inhibition by hydrogen peroxide (H(2)O(2)). Site-directed...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Rockefeller University Press
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129778/ https://www.ncbi.nlm.nih.gov/pubmed/33999118 http://dx.doi.org/10.1085/jgp.202012708 |