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Neonatal outcomes of pregnant women with COVID-19 in a developing country setup

BACKGROUND: Current evidence on vertical transmission of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) and neonatal outcome among exposed newborns is emerging and posing a challenge for preventive interventions. Perinatal transmission to the neonates especially during breastfeeding an...

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Autores principales: Nayak, Manas Kumar, Panda, Santosh Kumar, Panda, Subhra Snigdha, Rath, Soumini, Ghosh, Arpan, Mohakud, Nirmal Kumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taiwan Pediatric Association. Published by Elsevier Taiwan LLC. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129779/
https://www.ncbi.nlm.nih.gov/pubmed/34147430
http://dx.doi.org/10.1016/j.pedneo.2021.05.004
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author Nayak, Manas Kumar
Panda, Santosh Kumar
Panda, Subhra Snigdha
Rath, Soumini
Ghosh, Arpan
Mohakud, Nirmal Kumar
author_facet Nayak, Manas Kumar
Panda, Santosh Kumar
Panda, Subhra Snigdha
Rath, Soumini
Ghosh, Arpan
Mohakud, Nirmal Kumar
author_sort Nayak, Manas Kumar
collection PubMed
description BACKGROUND: Current evidence on vertical transmission of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) and neonatal outcome among exposed newborns is emerging and posing a challenge for preventive interventions. Perinatal transmission to the neonates especially during breastfeeding and rooming in is also relatively unknown. METHODS: This prospective observational study was conducted in Kalinga Institute of Medical Science (KIMS), Odisha state from 1st May to 20th October 2020. A total of 165 neonates born to SARS-CoV-2 infected mothers were enrolled. Real time polymerase chain reaction (RT PCR) testing was done in first 32 neonates in initial 24 h of life. RESULTS: The clinical characteristics of 162 mothers & 165 neonates were analyzed. Mode of delivery was by caesarian section in most (n = 103, 60%) cases. Three (3/32, 9.4%) inborn and 6 outborn neonates were SARS-CoV-2 positive. Thirty-eight (23%) babies needed neonatal intensive care. Clinical characteristics of neonates were meconium-stained amniotic fluid (MSAF [23.63%]), prematurity (16.9%), respiratory distress (10.5%), moderate to severe hypoxic ischemic encephalopathy (3.6%), sepsis (7%) and hyperbilirubinemia (8.7%). Out of 138 stable babies kept on mother side and initiated breast feeding, none of them developed any signs and symptoms attributable to SARS-CoV-2. Five (3%) neonates died in COVID hospital of which one baby was SARS-CoV-2 positive. CONCLUSION: There was an increased rate of incidences of hypoxic ischemic encephalopathy, meconium stained liquor and cesarean section delivery in COVID hospital. We found a possible vertical transmission in 9.4% cases. None of the neonates developed sign and symptoms of SARS-CoV-2 infection during rooming in and breast feeding.
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spelling pubmed-81297792021-05-18 Neonatal outcomes of pregnant women with COVID-19 in a developing country setup Nayak, Manas Kumar Panda, Santosh Kumar Panda, Subhra Snigdha Rath, Soumini Ghosh, Arpan Mohakud, Nirmal Kumar Pediatr Neonatol Original Article BACKGROUND: Current evidence on vertical transmission of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) and neonatal outcome among exposed newborns is emerging and posing a challenge for preventive interventions. Perinatal transmission to the neonates especially during breastfeeding and rooming in is also relatively unknown. METHODS: This prospective observational study was conducted in Kalinga Institute of Medical Science (KIMS), Odisha state from 1st May to 20th October 2020. A total of 165 neonates born to SARS-CoV-2 infected mothers were enrolled. Real time polymerase chain reaction (RT PCR) testing was done in first 32 neonates in initial 24 h of life. RESULTS: The clinical characteristics of 162 mothers & 165 neonates were analyzed. Mode of delivery was by caesarian section in most (n = 103, 60%) cases. Three (3/32, 9.4%) inborn and 6 outborn neonates were SARS-CoV-2 positive. Thirty-eight (23%) babies needed neonatal intensive care. Clinical characteristics of neonates were meconium-stained amniotic fluid (MSAF [23.63%]), prematurity (16.9%), respiratory distress (10.5%), moderate to severe hypoxic ischemic encephalopathy (3.6%), sepsis (7%) and hyperbilirubinemia (8.7%). Out of 138 stable babies kept on mother side and initiated breast feeding, none of them developed any signs and symptoms attributable to SARS-CoV-2. Five (3%) neonates died in COVID hospital of which one baby was SARS-CoV-2 positive. CONCLUSION: There was an increased rate of incidences of hypoxic ischemic encephalopathy, meconium stained liquor and cesarean section delivery in COVID hospital. We found a possible vertical transmission in 9.4% cases. None of the neonates developed sign and symptoms of SARS-CoV-2 infection during rooming in and breast feeding. Taiwan Pediatric Association. Published by Elsevier Taiwan LLC. 2021-09 2021-05-18 /pmc/articles/PMC8129779/ /pubmed/34147430 http://dx.doi.org/10.1016/j.pedneo.2021.05.004 Text en © 2021 Taiwan Pediatric Association. Published by Elsevier Taiwan LLC. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Original Article
Nayak, Manas Kumar
Panda, Santosh Kumar
Panda, Subhra Snigdha
Rath, Soumini
Ghosh, Arpan
Mohakud, Nirmal Kumar
Neonatal outcomes of pregnant women with COVID-19 in a developing country setup
title Neonatal outcomes of pregnant women with COVID-19 in a developing country setup
title_full Neonatal outcomes of pregnant women with COVID-19 in a developing country setup
title_fullStr Neonatal outcomes of pregnant women with COVID-19 in a developing country setup
title_full_unstemmed Neonatal outcomes of pregnant women with COVID-19 in a developing country setup
title_short Neonatal outcomes of pregnant women with COVID-19 in a developing country setup
title_sort neonatal outcomes of pregnant women with covid-19 in a developing country setup
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8129779/
https://www.ncbi.nlm.nih.gov/pubmed/34147430
http://dx.doi.org/10.1016/j.pedneo.2021.05.004
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