Cargando…

Allogeneic BK Virus-Specific T-Cell Treatment in 2 Patients With Progressive Multifocal Leukoencephalopathy

OBJECTIVE: Progressive multifocal leukoencephalopathy (PML) is a devastating demyelinating opportunistic infection of the brain caused by the ubiquitously distributed JC polyomavirus. There are no established treatment options to stop or slow down disease progression. In 2018, a case series of 3 pat...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hopfner, Franziska, Möhn, Nora, Eiz-Vesper, Britta, Maecker-Kolhoff, Britta, Gottlieb, Jens, Blasczyk, Rainer, Mahmoudi, Nima, Pars, Kaweh, Adams, Ortwin, Stangel, Martin, Wattjes, Mike P., Höglinger, Günter, Skripuletz, Thomas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130010/ https://www.ncbi.nlm.nih.gov/pubmed/34001660 http://dx.doi.org/10.1212/NXI.0000000000001020

Ejemplares similares

Innovative therapeutic concepts of progressive multifocal leukoencephalopathy
por: Möhn, Nora, et al.
Publicado: (2022)

PD-1-inhibitor pembrolizumab for treatment of progressive multifocal leukoencephalopathy
por: Möhn, Nora, et al.
Publicado: (2021)

Combined Treatment With Pembrolizumab and Allogenic BK Virus-Specific T Cells in Progressive Multifocal Leukoencephalopathy: A Case Report
por: Wicklein, Rebecca, et al.
Publicado: (2021)

Adoptive T-cell immunotherapy from third-party donors: characterization of donors and set up of a T-cell donor registry
por: Eiz-Vesper, Britta, et al.
Publicado: (2013)

Adoptive Allogeneic T-Cell Therapy Improves the Clinical Outcome of JC Virus Granule Cell Neuronopathy: A Case Report
por: Grote-Levi, Lea, et al.
Publicado: (2023)

Long-Term Follow-Up after Adoptive Transfer of BK-Virus-Specific T Cells in Hematopoietic Stem Cell Transplant Recipients
por: Koldehoff, Michael, et al.
Publicado: (2023)

Heat shock protein 70/peptide complexes: potent mediators for the generation of antiviral T cells particularly with regard to low precursor frequencies
por: Tischer, Sabine, et al.
Publicado: (2011)

Personalized adoptive immunotherapy for patients with EBV-associated tumors and complications: Evaluation of novel naturally processed and presented EBV-derived T-cell epitopes
por: Bieling, Maren, et al.
Publicado: (2017)

Discovery of immunodominant T-cell epitopes reveals penton protein as a second immunodominant target in human adenovirus infection
por: Tischer, Sabine, et al.
Publicado: (2016)

Robust Identification of Suitable T-Cell Subsets for Personalized CMV-Specific T-Cell Immunotherapy Using CD45RA and CD62L Microbeads
por: Mangare, Caroline, et al.
Publicado: (2019)

Tau-protein concentrations are not elevated in cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy
por: Möhn, Nora, et al.
Publicado: (2019)

Selective Effects of mTOR Inhibitor Sirolimus on Naïve and CMV-Specific T Cells Extending Its Applicable Range Beyond Immunosuppression
por: Bak, Szilvia, et al.
Publicado: (2018)

Targeted metabolomic profiling of cerebrospinal fluid from patients with progressive multifocal leukoencephalopathy
por: Luo, Yi, et al.
Publicado: (2020)

Inhibition of Heme Oxygenase-1 Activity Enhances Wilms Tumor-1-Specific T-Cell Responses in Cancer Immunotherapy
por: Schillingmann, Damaris A., et al.
Publicado: (2019)

High-intensity interval training in allogeneic adoptive T-cell immunotherapy – a big HIT?
por: Heinemann, Nele Carolin, et al.
Publicado: (2020)

Reinforcement of cell-mediated immunity driven by tumor-associated Epstein-Barr virus (EBV)-specific T cells during targeted B-cell therapy with rituximab
por: Tischer-Zimmermann, Sabine, et al.
Publicado: (2023)

Stem Cell Therapy in Neuroimmunological Diseases and Its Potential Neuroimmunological Complications
por: Konen, Franz Felix, et al.
Publicado: (2022)

Cerebrospinal fluid analysis in 108 patients with progressive multifocal leukoencephalopathy
por: Möhn, Nora, et al.
Publicado: (2020)

Antiviral T-Cell Frequencies in a Healthy Population: Reference Values for Evaluating Antiviral Immune Cell Profiles in Immunocompromised Patients
por: Schulze Lammers, Friederike C., et al.
Publicado: (2022)

Refractory Epstein-Barr Virus (EBV)-Related Post-transplant Lymphoproliferative Disease: Cure by Combined Brentuximab Vedotin and Allogeneic EBV-Specific T-Lymphocytes
por: Mika, Thomas, et al.
Publicado: (2019)

Adoptive Cell Transfer of Allogeneic Epstein–Barr Virus-Specific T Lymphocytes for Treatment of Refractory EBV-Associated Posttransplant Smooth Muscle Tumors: A Case Report
por: Hansen, Bjoern-Thore, et al.
Publicado: (2021)

Rapid generation of clinical-grade antiviral T cells: selection of suitable T-cell donors and GMP-compliant manufacturing of antiviral T cells
por: Tischer, Sabine, et al.
Publicado: (2014)

Comparative Analysis of Clinical-Scale IFN-γ-Positive T-Cell Enrichment Using Partially and Fully Integrated Platforms
por: Priesner, Christoph, et al.
Publicado: (2016)

Rapid and sustained T cell-based immunotherapy against invasive fungal disease via a combined two step procedure
por: Tischer-Zimmermann, Sabine, et al.
Publicado: (2023)

Impaired Functionality of Antiviral T Cells in G-CSF Mobilized Stem Cell Donors: Implications for the Selection of CTL Donor
por: Bunse, Carola E., et al.
Publicado: (2013)

Dissecting Epstein-Barr Virus-Specific T-Cell Responses After Allogeneic EBV-Specific T-Cell Transfer for Central Nervous System Posttransplant Lymphoproliferative Disease
por: Schultze-Florey, Rebecca E., et al.
Publicado: (2018)

BK polyomavirus associated progressive multifocal leukoencephalopathy in a person living with HIV
por: O'Kelly, Brendan, et al.
Publicado: (2021)

CAR-T cells and TRUCKs that recognize an EBNA-3C-derived epitope presented on HLA-B*35 control Epstein-Barr virus-associated lymphoproliferation
por: Dragon, Anna Christina, et al.
Publicado: (2020)

Secreted β(3)-Integrin Enhances Natural Killer Cell Activity against Acute Myeloid Leukemia Cells
por: Skaik, Younis, et al.
Publicado: (2014)

Intrathecal synthesis of anti-Hu antibodies distinguishes patients with paraneoplastic peripheral neuropathy and encephalitis
por: Schwenkenbecher, Philipp, et al.
Publicado: (2016)

Progressive Multifocal Leukoencephalopathy
por: Adang, Laura, et al.
Publicado: (2015)

Enhancement of Antiviral T-Cell Responses by Vitamin C Suggests New Strategies to Improve Manufacturing of Virus-Specific T Cells for Adoptive Immunotherapy
por: Laubert, Miriam, et al.
Publicado: (2022)

Fumaric Acids Do Not Directly Influence Gene Expression of Neuroprotective Factors in Highly Purified Rodent Astrocytes
por: Pars, Kaweh, et al.
Publicado: (2019)

HSP70 Enhances Immunosuppressive Function of CD4(+)CD25(+)FoxP3(+) T Regulatory Cells and Cytotoxicity in CD4(+)CD25(−) T Cells
por: Wachstein, Julian, et al.
Publicado: (2012)

CAR-Ts redirected against the Thomsen-Friedenreich antigen CD176 mediate specific elimination of malignant cells from leukemia and solid tumors
por: Dragon, Anna Christina, et al.
Publicado: (2023)

Fumaric Acids Directly Influence Gene Expression of Neuroprotective Factors in Rodent Microglia
por: Kronenberg, Jessica, et al.
Publicado: (2019)

Treatment of progressive multifocal leukoencephalopathy
por: Castle, Daniel, et al.
Publicado: (2019)

Mild progressive multifocal leukoencephalopathy after switching from natalizumab to ocrelizumab
por: Toorop, Alyssa A., et al.
Publicado: (2020)

Posttransplant Lymphoproliferative Disease after Pediatric Solid Organ Transplantation
por: Mynarek, Martin, et al.
Publicado: (2013)

Disease course and outcome of 15 monocentrically treated natalizumab-associated progressive multifocal leukoencephalopathy patients
por: Dahlhaus, Stefanie, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_qnounl6mbe2goifeq2id0lmoom