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Effect of antifoaming agent on benign colorectal tumors in colonoscopy: A meta-analysis

BACKGROUND: Although several trials have shown that the addition of antifoaming agents to polyethylene glycol (PEG) can improve bowel preparation, whether PEG plus antifoaming agents have a beneficial role in the detection of benign tumors during colonoscopy has yet to be confirmed. Our aim was to c...

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Autores principales: Zhang, Hu, Gong, Jing, Ma, Lin-Song, Jiang, Ting, Zhang, Heng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Baishideng Publishing Group Inc 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130091/
https://www.ncbi.nlm.nih.gov/pubmed/34046460
http://dx.doi.org/10.12998/wjcc.v9.i15.3607
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author Zhang, Hu
Gong, Jing
Ma, Lin-Song
Jiang, Ting
Zhang, Heng
author_facet Zhang, Hu
Gong, Jing
Ma, Lin-Song
Jiang, Ting
Zhang, Heng
author_sort Zhang, Hu
collection PubMed
description BACKGROUND: Although several trials have shown that the addition of antifoaming agents to polyethylene glycol (PEG) can improve bowel preparation, whether PEG plus antifoaming agents have a beneficial role in the detection of benign tumors during colonoscopy has yet to be confirmed. Our aim was to clarify whether adding simethicone to PEG solution could improve the detection of benign colorectal tumors. AIM: To clarify whether adding simethicone to PEG solution could improve the detection of benign colorectal tumors. METHODS: The PubMed, EMBASE, and Cochrane Library databases were searched for articles published prior to September 2019. The outcomes included the detection rates of colorectal adenomas and polyps. RESULT: Twenty studies were eligible. Although there was no difference in the colorectal adenoma detection rate (ADR), a significant effect of simethicone for diminutive adenomas (< 10 mm) was revealed in the group taking simethicone. We also found that simethicone could significantly improve the ADR in the proximal colon but did not affect the colorectal polyp detection rate. Furthermore, the subgroup analyses revealed a beneficial effect of simethicone on the ADR among Asians (P = 0.005) and those with an ADR < 25% (P = 0.003). Moreover, it was a significant finding that the low dose simethicone was as effective as the high dose one with respect to the detection of benign colorectal tumors. CONCLUSION: In summary, the addition of simethicone to PEG might improve the detection of diminutive adenomas in the right colon by colonoscopy in Asia. Low-dose simethicone was recommended for the detection of benign colorectal tumors. However, large clinical trials are necessary to validate our results and determine the ideal dose of simethicone.
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spelling pubmed-81300912021-05-26 Effect of antifoaming agent on benign colorectal tumors in colonoscopy: A meta-analysis Zhang, Hu Gong, Jing Ma, Lin-Song Jiang, Ting Zhang, Heng World J Clin Cases Meta-Analysis BACKGROUND: Although several trials have shown that the addition of antifoaming agents to polyethylene glycol (PEG) can improve bowel preparation, whether PEG plus antifoaming agents have a beneficial role in the detection of benign tumors during colonoscopy has yet to be confirmed. Our aim was to clarify whether adding simethicone to PEG solution could improve the detection of benign colorectal tumors. AIM: To clarify whether adding simethicone to PEG solution could improve the detection of benign colorectal tumors. METHODS: The PubMed, EMBASE, and Cochrane Library databases were searched for articles published prior to September 2019. The outcomes included the detection rates of colorectal adenomas and polyps. RESULT: Twenty studies were eligible. Although there was no difference in the colorectal adenoma detection rate (ADR), a significant effect of simethicone for diminutive adenomas (< 10 mm) was revealed in the group taking simethicone. We also found that simethicone could significantly improve the ADR in the proximal colon but did not affect the colorectal polyp detection rate. Furthermore, the subgroup analyses revealed a beneficial effect of simethicone on the ADR among Asians (P = 0.005) and those with an ADR < 25% (P = 0.003). Moreover, it was a significant finding that the low dose simethicone was as effective as the high dose one with respect to the detection of benign colorectal tumors. CONCLUSION: In summary, the addition of simethicone to PEG might improve the detection of diminutive adenomas in the right colon by colonoscopy in Asia. Low-dose simethicone was recommended for the detection of benign colorectal tumors. However, large clinical trials are necessary to validate our results and determine the ideal dose of simethicone. Baishideng Publishing Group Inc 2021-05-26 2021-05-26 /pmc/articles/PMC8130091/ /pubmed/34046460 http://dx.doi.org/10.12998/wjcc.v9.i15.3607 Text en ©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved. https://creativecommons.org/licenses/by-nc/4.0/This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.
spellingShingle Meta-Analysis
Zhang, Hu
Gong, Jing
Ma, Lin-Song
Jiang, Ting
Zhang, Heng
Effect of antifoaming agent on benign colorectal tumors in colonoscopy: A meta-analysis
title Effect of antifoaming agent on benign colorectal tumors in colonoscopy: A meta-analysis
title_full Effect of antifoaming agent on benign colorectal tumors in colonoscopy: A meta-analysis
title_fullStr Effect of antifoaming agent on benign colorectal tumors in colonoscopy: A meta-analysis
title_full_unstemmed Effect of antifoaming agent on benign colorectal tumors in colonoscopy: A meta-analysis
title_short Effect of antifoaming agent on benign colorectal tumors in colonoscopy: A meta-analysis
title_sort effect of antifoaming agent on benign colorectal tumors in colonoscopy: a meta-analysis
topic Meta-Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130091/
https://www.ncbi.nlm.nih.gov/pubmed/34046460
http://dx.doi.org/10.12998/wjcc.v9.i15.3607
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