Synthesis of asymmetrical diaminobis(alkoxo)-bisphenol compounds and their C(1)-symmetrical mono-ligated titanium(iv) complexes as highly stable highly active antitumor compounds

Asymmetrical 2,2′-((ethane-1,2-diylbis((2-hydroxyethyl)azanediyl))bis(methylene))diphenol substituted compounds and their C(1)-symmetrical diaminobis(phenolato)-bis(alkoxo) titanium(iv) complexes were synthesized, with one symmetrical analogue. X-ray crystallography corroborated tight ligand binding...

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Detalles Bibliográficos
Autores principales: Nahari, Gilad, Tshuva, Edit Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130176/
https://www.ncbi.nlm.nih.gov/pubmed/33949509
http://dx.doi.org/10.1039/d1dt00219h
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author Nahari, Gilad
Tshuva, Edit Y.
author_facet Nahari, Gilad
Tshuva, Edit Y.
author_sort Nahari, Gilad
collection PubMed
description Asymmetrical 2,2′-((ethane-1,2-diylbis((2-hydroxyethyl)azanediyl))bis(methylene))diphenol substituted compounds and their C(1)-symmetrical diaminobis(phenolato)-bis(alkoxo) titanium(iv) complexes were synthesized, with one symmetrical analogue. X-ray crystallography corroborated tight ligand binding. Different substitutions on the two aromatic rings enabled fine-tuning of the complex properties, giving enhanced solubility, high anticancer activity (IC(50) < 4 μM), and significant hydrolytic stability.
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spelling pubmed-81301762021-05-25 Synthesis of asymmetrical diaminobis(alkoxo)-bisphenol compounds and their C(1)-symmetrical mono-ligated titanium(iv) complexes as highly stable highly active antitumor compounds Nahari, Gilad Tshuva, Edit Y. Dalton Trans Chemistry Asymmetrical 2,2′-((ethane-1,2-diylbis((2-hydroxyethyl)azanediyl))bis(methylene))diphenol substituted compounds and their C(1)-symmetrical diaminobis(phenolato)-bis(alkoxo) titanium(iv) complexes were synthesized, with one symmetrical analogue. X-ray crystallography corroborated tight ligand binding. Different substitutions on the two aromatic rings enabled fine-tuning of the complex properties, giving enhanced solubility, high anticancer activity (IC(50) < 4 μM), and significant hydrolytic stability. The Royal Society of Chemistry 2021-05-04 /pmc/articles/PMC8130176/ /pubmed/33949509 http://dx.doi.org/10.1039/d1dt00219h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Nahari, Gilad
Tshuva, Edit Y.
Synthesis of asymmetrical diaminobis(alkoxo)-bisphenol compounds and their C(1)-symmetrical mono-ligated titanium(iv) complexes as highly stable highly active antitumor compounds
title Synthesis of asymmetrical diaminobis(alkoxo)-bisphenol compounds and their C(1)-symmetrical mono-ligated titanium(iv) complexes as highly stable highly active antitumor compounds
title_full Synthesis of asymmetrical diaminobis(alkoxo)-bisphenol compounds and their C(1)-symmetrical mono-ligated titanium(iv) complexes as highly stable highly active antitumor compounds
title_fullStr Synthesis of asymmetrical diaminobis(alkoxo)-bisphenol compounds and their C(1)-symmetrical mono-ligated titanium(iv) complexes as highly stable highly active antitumor compounds
title_full_unstemmed Synthesis of asymmetrical diaminobis(alkoxo)-bisphenol compounds and their C(1)-symmetrical mono-ligated titanium(iv) complexes as highly stable highly active antitumor compounds
title_short Synthesis of asymmetrical diaminobis(alkoxo)-bisphenol compounds and their C(1)-symmetrical mono-ligated titanium(iv) complexes as highly stable highly active antitumor compounds
title_sort synthesis of asymmetrical diaminobis(alkoxo)-bisphenol compounds and their c(1)-symmetrical mono-ligated titanium(iv) complexes as highly stable highly active antitumor compounds
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130176/
https://www.ncbi.nlm.nih.gov/pubmed/33949509
http://dx.doi.org/10.1039/d1dt00219h
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