SARS-CoV-2 variants: Subversion of antibody response and predicted impact on T cell recognition

COVID-19 variants of concern, including B.1.1.7, B.1.351, and P.1, encompass mutations facilitating immune evasion. Neutralizing antibody recognition and function may be variably impaired. We considered the impact of mutations on T cell responses. Mutations could be neutral or result in either loss...

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Detalles Bibliográficos
Autores principales: Altmann, Daniel M., Reynolds, Catherine J., Boyton, Rosemary J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130189/
https://www.ncbi.nlm.nih.gov/pubmed/34027499
http://dx.doi.org/10.1016/j.xcrm.2021.100286
Descripción
Sumario:COVID-19 variants of concern, including B.1.1.7, B.1.351, and P.1, encompass mutations facilitating immune evasion. Neutralizing antibody recognition and function may be variably impaired. We considered the impact of mutations on T cell responses. Mutations could be neutral or result in either loss or gain of predicted epitopes depending on HLA type.

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