SARS-CoV-2 variants: Subversion of antibody response and predicted impact on T cell recognition

COVID-19 variants of concern, including B.1.1.7, B.1.351, and P.1, encompass mutations facilitating immune evasion. Neutralizing antibody recognition and function may be variably impaired. We considered the impact of mutations on T cell responses. Mutations could be neutral or result in either loss...

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Detalles Bibliográficos
Autores principales: Altmann, Daniel M., Reynolds, Catherine J., Boyton, Rosemary J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130189/
https://www.ncbi.nlm.nih.gov/pubmed/34027499
http://dx.doi.org/10.1016/j.xcrm.2021.100286
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author Altmann, Daniel M.
Reynolds, Catherine J.
Boyton, Rosemary J.
author_facet Altmann, Daniel M.
Reynolds, Catherine J.
Boyton, Rosemary J.
author_sort Altmann, Daniel M.
collection PubMed
description COVID-19 variants of concern, including B.1.1.7, B.1.351, and P.1, encompass mutations facilitating immune evasion. Neutralizing antibody recognition and function may be variably impaired. We considered the impact of mutations on T cell responses. Mutations could be neutral or result in either loss or gain of predicted epitopes depending on HLA type.
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spelling pubmed-81301892021-05-18 SARS-CoV-2 variants: Subversion of antibody response and predicted impact on T cell recognition Altmann, Daniel M. Reynolds, Catherine J. Boyton, Rosemary J. Cell Rep Med Commentary COVID-19 variants of concern, including B.1.1.7, B.1.351, and P.1, encompass mutations facilitating immune evasion. Neutralizing antibody recognition and function may be variably impaired. We considered the impact of mutations on T cell responses. Mutations could be neutral or result in either loss or gain of predicted epitopes depending on HLA type. Elsevier 2021-05-18 /pmc/articles/PMC8130189/ /pubmed/34027499 http://dx.doi.org/10.1016/j.xcrm.2021.100286 Text en © 2021. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Commentary
Altmann, Daniel M.
Reynolds, Catherine J.
Boyton, Rosemary J.
SARS-CoV-2 variants: Subversion of antibody response and predicted impact on T cell recognition
title SARS-CoV-2 variants: Subversion of antibody response and predicted impact on T cell recognition
title_full SARS-CoV-2 variants: Subversion of antibody response and predicted impact on T cell recognition
title_fullStr SARS-CoV-2 variants: Subversion of antibody response and predicted impact on T cell recognition
title_full_unstemmed SARS-CoV-2 variants: Subversion of antibody response and predicted impact on T cell recognition
title_short SARS-CoV-2 variants: Subversion of antibody response and predicted impact on T cell recognition
title_sort sars-cov-2 variants: subversion of antibody response and predicted impact on t cell recognition
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130189/
https://www.ncbi.nlm.nih.gov/pubmed/34027499
http://dx.doi.org/10.1016/j.xcrm.2021.100286
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