Unilateral facial injection of Botulinum neurotoxin A attenuates bilateral trigeminal neuropathic pain and anxiety-like behaviors through inhibition of TLR2-mediated neuroinflammation in mice

OBJECTIVES: In this study, we investigated the possible analgesic effects of Botulinum toxin type A (BoNT/A) on trigeminal neuralgia (TN). A modified TN mouse model was established by chronic constriction injury of the distal infraorbital nerve (dIoN-CCI) in mice, and the possible roles of microglia...

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Detalles Bibliográficos
Autores principales: Chen, Wei-Jia, Niu, Jing-Qi, Chen, Yi-Ting, Deng, Wen-Jing, Xu, Ying-Ying, Liu, Jing, Luo, Wei-Feng, Liu, Tong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Milan 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130347/
https://www.ncbi.nlm.nih.gov/pubmed/34000998
http://dx.doi.org/10.1186/s10194-021-01254-2

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