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One-year urinary and sexual outcome trajectories among prostate cancer patients treated by radical prostatectomy: a prospective study
BACKGROUND: To examine one-year trajectories of urinary and sexual outcomes, and correlates of these trajectories, among prostate cancer patients treated by radical prostatectomy (RP). METHODS: Study participants were recruited from 2011 to 2014 at two US institutions. Self-reported urinary and sexu...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130427/ https://www.ncbi.nlm.nih.gov/pubmed/34001094 http://dx.doi.org/10.1186/s12894-021-00845-0 |
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author | Yang, Lin Lee, Jung Ae Heer, Emily Pernar, Claire Colditz, Graham A. Pakpahan, Ratna Imm, Kellie R. Kim, Eric H. Grubb, Robert L. Wolin, Kathleen Y. Kibel, Adam S. Sutcliffe, Siobhan |
author_facet | Yang, Lin Lee, Jung Ae Heer, Emily Pernar, Claire Colditz, Graham A. Pakpahan, Ratna Imm, Kellie R. Kim, Eric H. Grubb, Robert L. Wolin, Kathleen Y. Kibel, Adam S. Sutcliffe, Siobhan |
author_sort | Yang, Lin |
collection | PubMed |
description | BACKGROUND: To examine one-year trajectories of urinary and sexual outcomes, and correlates of these trajectories, among prostate cancer patients treated by radical prostatectomy (RP). METHODS: Study participants were recruited from 2011 to 2014 at two US institutions. Self-reported urinary and sexual outcomes were measured at baseline before surgery, and 5 weeks, 6 months and 12 months after surgery, using the modified Expanded Prostate Cancer Index Composite-50 (EPIC-50). Changes in EPIC-50 scores from baseline were categorized as improved (beyond baseline), maintained, or impaired (below baseline), using previously-reported minimum clinically important differences. RESULTS: Of the 426 eligible participants who completed the baseline survey, 395 provided data on at least one EPIC-50 sub-scale at 5 weeks and 12 months, and were analyzed. Although all mean EPIC-50 scores declined markedly 5 weeks after surgery and then recovered to near (incontinence-related outcomes) or below (sexual outcomes) baseline levels by 12 months post-surgery, some men experienced improvement beyond their baseline levels on each sub-scale (3.3–51% depending on the sub-scale). Having benign prostatic hyperplasia (BPH) at baseline (prostate size ≥ 40 g; an International Prostate Symptom Index Score ≥ 8; or using BPH medications) was associated with post-surgical improvements in voiding dysfunction-related bother at 5 weeks (OR = 3.9, 95% CI: 2.1–7.2) and 12 months (OR = 3.3, 95% CI: 2.0–5.7); and in sexual bother at 5 weeks (OR = 5.7, 95% CI:1.7–19.3) and 12 months (OR = 3.0, 95% CI: 1.2–7.1). CONCLUSIONS: Our findings provide additional support for considering baseline BPH symptoms when selecting the best therapy for early-stage prostate cancer. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12894-021-00845-0. |
format | Online Article Text |
id | pubmed-8130427 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-81304272021-05-19 One-year urinary and sexual outcome trajectories among prostate cancer patients treated by radical prostatectomy: a prospective study Yang, Lin Lee, Jung Ae Heer, Emily Pernar, Claire Colditz, Graham A. Pakpahan, Ratna Imm, Kellie R. Kim, Eric H. Grubb, Robert L. Wolin, Kathleen Y. Kibel, Adam S. Sutcliffe, Siobhan BMC Urol Research Article BACKGROUND: To examine one-year trajectories of urinary and sexual outcomes, and correlates of these trajectories, among prostate cancer patients treated by radical prostatectomy (RP). METHODS: Study participants were recruited from 2011 to 2014 at two US institutions. Self-reported urinary and sexual outcomes were measured at baseline before surgery, and 5 weeks, 6 months and 12 months after surgery, using the modified Expanded Prostate Cancer Index Composite-50 (EPIC-50). Changes in EPIC-50 scores from baseline were categorized as improved (beyond baseline), maintained, or impaired (below baseline), using previously-reported minimum clinically important differences. RESULTS: Of the 426 eligible participants who completed the baseline survey, 395 provided data on at least one EPIC-50 sub-scale at 5 weeks and 12 months, and were analyzed. Although all mean EPIC-50 scores declined markedly 5 weeks after surgery and then recovered to near (incontinence-related outcomes) or below (sexual outcomes) baseline levels by 12 months post-surgery, some men experienced improvement beyond their baseline levels on each sub-scale (3.3–51% depending on the sub-scale). Having benign prostatic hyperplasia (BPH) at baseline (prostate size ≥ 40 g; an International Prostate Symptom Index Score ≥ 8; or using BPH medications) was associated with post-surgical improvements in voiding dysfunction-related bother at 5 weeks (OR = 3.9, 95% CI: 2.1–7.2) and 12 months (OR = 3.3, 95% CI: 2.0–5.7); and in sexual bother at 5 weeks (OR = 5.7, 95% CI:1.7–19.3) and 12 months (OR = 3.0, 95% CI: 1.2–7.1). CONCLUSIONS: Our findings provide additional support for considering baseline BPH symptoms when selecting the best therapy for early-stage prostate cancer. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12894-021-00845-0. BioMed Central 2021-05-17 /pmc/articles/PMC8130427/ /pubmed/34001094 http://dx.doi.org/10.1186/s12894-021-00845-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Article Yang, Lin Lee, Jung Ae Heer, Emily Pernar, Claire Colditz, Graham A. Pakpahan, Ratna Imm, Kellie R. Kim, Eric H. Grubb, Robert L. Wolin, Kathleen Y. Kibel, Adam S. Sutcliffe, Siobhan One-year urinary and sexual outcome trajectories among prostate cancer patients treated by radical prostatectomy: a prospective study |
title | One-year urinary and sexual outcome trajectories among prostate cancer patients treated by radical prostatectomy: a prospective study |
title_full | One-year urinary and sexual outcome trajectories among prostate cancer patients treated by radical prostatectomy: a prospective study |
title_fullStr | One-year urinary and sexual outcome trajectories among prostate cancer patients treated by radical prostatectomy: a prospective study |
title_full_unstemmed | One-year urinary and sexual outcome trajectories among prostate cancer patients treated by radical prostatectomy: a prospective study |
title_short | One-year urinary and sexual outcome trajectories among prostate cancer patients treated by radical prostatectomy: a prospective study |
title_sort | one-year urinary and sexual outcome trajectories among prostate cancer patients treated by radical prostatectomy: a prospective study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130427/ https://www.ncbi.nlm.nih.gov/pubmed/34001094 http://dx.doi.org/10.1186/s12894-021-00845-0 |
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