Survival differences of patients with ureteral versus pelvicalyceal tumours: a systematic review and meta-analysis

INTRODUCTION: Worse survival in upper tract urothelial carcinoma (UTUC) in the presence of a tumour in the ureter vs. pelvicalyceal tumours is reported in some studies; however, the definition of ureteral involvement (UI) varies across studies. We systematically evaluated evidence regarding the prog...

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Detalles Bibliográficos
Autores principales: Kaczmarek, Krystian, Lemiński, Artur, Gołąb, Adam, Słojewski, Marcin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2019
Materias:
Systematic review/Meta-analysis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130483/
https://www.ncbi.nlm.nih.gov/pubmed/34025829
http://dx.doi.org/10.5114/aoms.2019.89893
Descripción
Sumario:INTRODUCTION: Worse survival in upper tract urothelial carcinoma (UTUC) in the presence of a tumour in the ureter vs. pelvicalyceal tumours is reported in some studies; however, the definition of ureteral involvement (UI) varies across studies. We systematically evaluated evidence regarding the prognostic role of UI in overall and cancer-specific survival of patients with UTUC. MATERIAL AND METHODS: A systematic search of PubMed, Scopus and Web of Knowledge was performed in March 2018. RESULTS: The results were presented as a comparison between ureteral vs. pelvicalyceal tumours. A total of 14,895 patients were identified. Cumulative analyses indicated that UI worsens cancer-specific survival (CSS) and overall survival (OS), with a pooled HR of 1.52 (p < 0.001) and 1.39 (p = 0.004), respectively. CONCLUSIONS: Our meta-analysis identified UI in UTUC as an adverse prognostic factor.

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