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Diffuse trophoblast damage is the hallmark of SARS-CoV-2-associated fetal demise
Placental pathology in SARS-CoV-2-infected pregnancies seems rather unspecific. However, the identification of the placental lesions due to SARS-CoV-2 infection would be a significant advance in order to improve the management of these pregnancies and to identify the mechanisms involved in a possibl...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
United States & Canadian Academy of Pathology.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130566/ https://www.ncbi.nlm.nih.gov/pubmed/34006935 http://dx.doi.org/10.1038/s41379-021-00827-5 |
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author | Garrido-Pontnou, Marta Navarro, Alexandra Camacho, Jessica Crispi, Fàtima Alguacil-Guillén, Marina Moreno-Baró, Anna Hernandez-Losa, Javier Sesé, Marta Ramón y Cajal, Santiago Garcia Ruíz, Itziar Serrano, Berta Garcia-Aguilar, Paula Suy, Anna Ferreres, Joan Carles Nadal, Alfons |
author_facet | Garrido-Pontnou, Marta Navarro, Alexandra Camacho, Jessica Crispi, Fàtima Alguacil-Guillén, Marina Moreno-Baró, Anna Hernandez-Losa, Javier Sesé, Marta Ramón y Cajal, Santiago Garcia Ruíz, Itziar Serrano, Berta Garcia-Aguilar, Paula Suy, Anna Ferreres, Joan Carles Nadal, Alfons |
author_sort | Garrido-Pontnou, Marta |
collection | PubMed |
description | Placental pathology in SARS-CoV-2-infected pregnancies seems rather unspecific. However, the identification of the placental lesions due to SARS-CoV-2 infection would be a significant advance in order to improve the management of these pregnancies and to identify the mechanisms involved in a possible vertical transmission. The pathological findings in placentas delivered from 198 SARS-CoV-2-positive pregnant women were investigated for the presence of lesions associated with placental SARS-CoV-2 infection. SARS-CoV-2 infection was investigated in placental tissues through immunohistochemistry, and positive cases were further confirmed by in situ hybridization. SARS-CoV-2 infection was also investigated by RT-PCR in 33 cases, including all the immunohistochemically positive cases. Nine cases were SARS-CoV-2-positive by immunohistochemistry, in situ hybridization, and RT-PCR. These placentas showed lesions characterized by villous trophoblast necrosis with intervillous space collapse and variable amounts of mixed intervillous inflammatory infiltrate and perivillous fibrinoid deposition. Such lesions ranged from focal to massively widespread in five cases, resulting in intrauterine fetal death. Two of the stillborn fetuses showed some evidence of SARS-CoV-2 positivity. The remaining 189 placentas did not show similar lesions. The strong association between trophoblastic damage and placenta SARS-CoV-2 infection suggests that this lesion is a specific marker of SARS-CoV-2 infection in placenta. Diffuse trophoblastic damage, massively affecting chorionic villous tissue, can result in fetal death associated with COVID-19 disease. |
format | Online Article Text |
id | pubmed-8130566 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | United States & Canadian Academy of Pathology. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81305662021-05-18 Diffuse trophoblast damage is the hallmark of SARS-CoV-2-associated fetal demise Garrido-Pontnou, Marta Navarro, Alexandra Camacho, Jessica Crispi, Fàtima Alguacil-Guillén, Marina Moreno-Baró, Anna Hernandez-Losa, Javier Sesé, Marta Ramón y Cajal, Santiago Garcia Ruíz, Itziar Serrano, Berta Garcia-Aguilar, Paula Suy, Anna Ferreres, Joan Carles Nadal, Alfons Mod Pathol Article Placental pathology in SARS-CoV-2-infected pregnancies seems rather unspecific. However, the identification of the placental lesions due to SARS-CoV-2 infection would be a significant advance in order to improve the management of these pregnancies and to identify the mechanisms involved in a possible vertical transmission. The pathological findings in placentas delivered from 198 SARS-CoV-2-positive pregnant women were investigated for the presence of lesions associated with placental SARS-CoV-2 infection. SARS-CoV-2 infection was investigated in placental tissues through immunohistochemistry, and positive cases were further confirmed by in situ hybridization. SARS-CoV-2 infection was also investigated by RT-PCR in 33 cases, including all the immunohistochemically positive cases. Nine cases were SARS-CoV-2-positive by immunohistochemistry, in situ hybridization, and RT-PCR. These placentas showed lesions characterized by villous trophoblast necrosis with intervillous space collapse and variable amounts of mixed intervillous inflammatory infiltrate and perivillous fibrinoid deposition. Such lesions ranged from focal to massively widespread in five cases, resulting in intrauterine fetal death. Two of the stillborn fetuses showed some evidence of SARS-CoV-2 positivity. The remaining 189 placentas did not show similar lesions. The strong association between trophoblastic damage and placenta SARS-CoV-2 infection suggests that this lesion is a specific marker of SARS-CoV-2 infection in placenta. Diffuse trophoblastic damage, massively affecting chorionic villous tissue, can result in fetal death associated with COVID-19 disease. United States & Canadian Academy of Pathology. 2021-09 2023-01-05 /pmc/articles/PMC8130566/ /pubmed/34006935 http://dx.doi.org/10.1038/s41379-021-00827-5 Text en © 2021 United States & Canadian Academy of Pathology. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Garrido-Pontnou, Marta Navarro, Alexandra Camacho, Jessica Crispi, Fàtima Alguacil-Guillén, Marina Moreno-Baró, Anna Hernandez-Losa, Javier Sesé, Marta Ramón y Cajal, Santiago Garcia Ruíz, Itziar Serrano, Berta Garcia-Aguilar, Paula Suy, Anna Ferreres, Joan Carles Nadal, Alfons Diffuse trophoblast damage is the hallmark of SARS-CoV-2-associated fetal demise |
title | Diffuse trophoblast damage is the hallmark of SARS-CoV-2-associated fetal demise |
title_full | Diffuse trophoblast damage is the hallmark of SARS-CoV-2-associated fetal demise |
title_fullStr | Diffuse trophoblast damage is the hallmark of SARS-CoV-2-associated fetal demise |
title_full_unstemmed | Diffuse trophoblast damage is the hallmark of SARS-CoV-2-associated fetal demise |
title_short | Diffuse trophoblast damage is the hallmark of SARS-CoV-2-associated fetal demise |
title_sort | diffuse trophoblast damage is the hallmark of sars-cov-2-associated fetal demise |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130566/ https://www.ncbi.nlm.nih.gov/pubmed/34006935 http://dx.doi.org/10.1038/s41379-021-00827-5 |
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