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Recent advances in the protective role of hydrogen sulfide in myocardial ischemia/reperfusion injury: a narrative review

Hydrogen sulfide (H(2)S) is recognized to be a novel mediator after carbon monoxide and nitric oxide in the organism. It can be produced in various mammalian tissues and exert many physiological effects in many systems including the cardiovascular system. A great amount of recent studies have demons...

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Autores principales: Zhang, Meng-Ling, Peng, Wei, Ni, Jian-Qiang, Chen, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130667/
https://www.ncbi.nlm.nih.gov/pubmed/33818448
http://dx.doi.org/10.4103/2045-9912.311499
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author Zhang, Meng-Ling
Peng, Wei
Ni, Jian-Qiang
Chen, Gang
author_facet Zhang, Meng-Ling
Peng, Wei
Ni, Jian-Qiang
Chen, Gang
author_sort Zhang, Meng-Ling
collection PubMed
description Hydrogen sulfide (H(2)S) is recognized to be a novel mediator after carbon monoxide and nitric oxide in the organism. It can be produced in various mammalian tissues and exert many physiological effects in many systems including the cardiovascular system. A great amount of recent studies have demonstrated that endogenous H(2)S and exogenous H(2)S-releasing compounds (such as NaHS, Na(2)S, and GYY4137) provide protection in many cardiovascular diseases, such as ischemia/reperfusion injury, heart failure, cardiac hypertrophy, and atherosclerosis. In recent years, many mechanisms have been proposed and verified the protective role exhibited by H(2)S against myocardial ischemia/reperfusion injury, and this review is to demonstrate the protective role of exogenous and endogenous H(2)S on myocardial ischemia/reperfusion injury.
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spelling pubmed-81306672021-05-25 Recent advances in the protective role of hydrogen sulfide in myocardial ischemia/reperfusion injury: a narrative review Zhang, Meng-Ling Peng, Wei Ni, Jian-Qiang Chen, Gang Med Gas Res Review Hydrogen sulfide (H(2)S) is recognized to be a novel mediator after carbon monoxide and nitric oxide in the organism. It can be produced in various mammalian tissues and exert many physiological effects in many systems including the cardiovascular system. A great amount of recent studies have demonstrated that endogenous H(2)S and exogenous H(2)S-releasing compounds (such as NaHS, Na(2)S, and GYY4137) provide protection in many cardiovascular diseases, such as ischemia/reperfusion injury, heart failure, cardiac hypertrophy, and atherosclerosis. In recent years, many mechanisms have been proposed and verified the protective role exhibited by H(2)S against myocardial ischemia/reperfusion injury, and this review is to demonstrate the protective role of exogenous and endogenous H(2)S on myocardial ischemia/reperfusion injury. Wolters Kluwer - Medknow 2021-03-26 /pmc/articles/PMC8130667/ /pubmed/33818448 http://dx.doi.org/10.4103/2045-9912.311499 Text en Copyright: © 2021 Medical Gas Research https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Review
Zhang, Meng-Ling
Peng, Wei
Ni, Jian-Qiang
Chen, Gang
Recent advances in the protective role of hydrogen sulfide in myocardial ischemia/reperfusion injury: a narrative review
title Recent advances in the protective role of hydrogen sulfide in myocardial ischemia/reperfusion injury: a narrative review
title_full Recent advances in the protective role of hydrogen sulfide in myocardial ischemia/reperfusion injury: a narrative review
title_fullStr Recent advances in the protective role of hydrogen sulfide in myocardial ischemia/reperfusion injury: a narrative review
title_full_unstemmed Recent advances in the protective role of hydrogen sulfide in myocardial ischemia/reperfusion injury: a narrative review
title_short Recent advances in the protective role of hydrogen sulfide in myocardial ischemia/reperfusion injury: a narrative review
title_sort recent advances in the protective role of hydrogen sulfide in myocardial ischemia/reperfusion injury: a narrative review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130667/
https://www.ncbi.nlm.nih.gov/pubmed/33818448
http://dx.doi.org/10.4103/2045-9912.311499
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