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NKTR-255, a novel polymer-conjugated rhIL-15 with potent antitumor efficacy

BACKGROUND: NKTR-255 is a novel polyethylene glycol-conjugate of recombinant human interleukin-15 (rhIL-15), which was designed to retain all known receptor binding interactions of the IL-15 molecule. We explored the biologic and pharmacologic differences between endogenous IL-15 receptor α (IL-15Rα...

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Detalles Bibliográficos
Autores principales:	Miyazaki, Takahiro, Maiti, Mekhala, Hennessy, Marlene, Chang, Thomas, Kuo, Peiwen, Addepalli, Murali, Obalapur, Palakshi, Sheibani, Sara, Wilczek, Joanna, Pena, Rhoneil, Quach, Phi, Cetz, Janet, Moffett, Andrew, Tang, Yinyan, Kirk, Peter, Huang, Jicai, Sheng, Dawei, Zhang, Ping, Rubas, Werner, Madakamutil, Loui, Kivimäe, Saul, Zalevsky, Jonathan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2021
Materias:	Clinical/Translational Cancer Immunotherapy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130760/ https://www.ncbi.nlm.nih.gov/pubmed/34001523 http://dx.doi.org/10.1136/jitc-2020-002024

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