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Lack of association between vitamin D insufficiency and clinical outcomes of patients with COVID-19 infection
BACKGROUND: A protective effect of vitamin D against COVID-19 infection is under investigation. We aimed to analyze the effect of vitamin D sufficiency on the clinical outcomes of patients infected with COVID-19. METHODS: In this cross-sectional study we analyzed the vitamin D levels of COVID-19 pat...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130780/ https://www.ncbi.nlm.nih.gov/pubmed/34006228 http://dx.doi.org/10.1186/s12879-021-06168-7 |
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author | Davoudi, Alireza Najafi, Narges Aarabi, Mohsen Tayebi, Atefeh Nikaeen, Roja Izadyar, Hamideh Salar, Zahra Delavarian, Leila Vaseghi, Narges Daftarian, Zahra Ahangarkani, Fatemeh |
author_facet | Davoudi, Alireza Najafi, Narges Aarabi, Mohsen Tayebi, Atefeh Nikaeen, Roja Izadyar, Hamideh Salar, Zahra Delavarian, Leila Vaseghi, Narges Daftarian, Zahra Ahangarkani, Fatemeh |
author_sort | Davoudi, Alireza |
collection | PubMed |
description | BACKGROUND: A protective effect of vitamin D against COVID-19 infection is under investigation. We aimed to analyze the effect of vitamin D sufficiency on the clinical outcomes of patients infected with COVID-19. METHODS: In this cross-sectional study we analyzed the vitamin D levels of COVID-19 patients who were admitted to Razi Hospital (an infectious disease referral center in Mazandaran province in northern Iran) from February to March 2020. Overall, a cutoff point of 30 ng/mL was used for the definition of vitamin D sufficiency. RESULTS: One hundred fifty-three patients were analyzed in this study who had laboratory documentation of a 25(OH) D level at the time of hospitalization. The vitamin D levels of the patients were 27.19 ± 20.17 ng/mL. In total, 62.7% (n = 96) of the patients had a 25(OH) D level of less than 30 ng/mL and 37.25% (n = 57) had a 25(OH) D level of more than 30 ng/mL. In total, 49% (n = 75) of the patients suffered from at least one underlying disease. The univariate and multivariable regression showed that vitamin D sufficiency was not associated with a statistically significant lower risk of adverse clinical outcomes of COVID-19 such as duration of hospitalization and severity of infection (P > 0.05). CONCLUSIONS: Sufficient vitamin D levels were not found to be protective against adverse clinical outcomes in patients infected with COVID-19. Chronic disorders in COVID-19 patients were found to have greater relevance than vitamin D levels in determining the adverse outcomes of the infection. Further studies are needed to determine the role of vitamin D level in predicting the outcomes of COVID-19 infection. |
format | Online Article Text |
id | pubmed-8130780 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-81307802021-05-19 Lack of association between vitamin D insufficiency and clinical outcomes of patients with COVID-19 infection Davoudi, Alireza Najafi, Narges Aarabi, Mohsen Tayebi, Atefeh Nikaeen, Roja Izadyar, Hamideh Salar, Zahra Delavarian, Leila Vaseghi, Narges Daftarian, Zahra Ahangarkani, Fatemeh BMC Infect Dis Research BACKGROUND: A protective effect of vitamin D against COVID-19 infection is under investigation. We aimed to analyze the effect of vitamin D sufficiency on the clinical outcomes of patients infected with COVID-19. METHODS: In this cross-sectional study we analyzed the vitamin D levels of COVID-19 patients who were admitted to Razi Hospital (an infectious disease referral center in Mazandaran province in northern Iran) from February to March 2020. Overall, a cutoff point of 30 ng/mL was used for the definition of vitamin D sufficiency. RESULTS: One hundred fifty-three patients were analyzed in this study who had laboratory documentation of a 25(OH) D level at the time of hospitalization. The vitamin D levels of the patients were 27.19 ± 20.17 ng/mL. In total, 62.7% (n = 96) of the patients had a 25(OH) D level of less than 30 ng/mL and 37.25% (n = 57) had a 25(OH) D level of more than 30 ng/mL. In total, 49% (n = 75) of the patients suffered from at least one underlying disease. The univariate and multivariable regression showed that vitamin D sufficiency was not associated with a statistically significant lower risk of adverse clinical outcomes of COVID-19 such as duration of hospitalization and severity of infection (P > 0.05). CONCLUSIONS: Sufficient vitamin D levels were not found to be protective against adverse clinical outcomes in patients infected with COVID-19. Chronic disorders in COVID-19 patients were found to have greater relevance than vitamin D levels in determining the adverse outcomes of the infection. Further studies are needed to determine the role of vitamin D level in predicting the outcomes of COVID-19 infection. BioMed Central 2021-05-18 /pmc/articles/PMC8130780/ /pubmed/34006228 http://dx.doi.org/10.1186/s12879-021-06168-7 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Davoudi, Alireza Najafi, Narges Aarabi, Mohsen Tayebi, Atefeh Nikaeen, Roja Izadyar, Hamideh Salar, Zahra Delavarian, Leila Vaseghi, Narges Daftarian, Zahra Ahangarkani, Fatemeh Lack of association between vitamin D insufficiency and clinical outcomes of patients with COVID-19 infection |
title | Lack of association between vitamin D insufficiency and clinical outcomes of patients with COVID-19 infection |
title_full | Lack of association between vitamin D insufficiency and clinical outcomes of patients with COVID-19 infection |
title_fullStr | Lack of association between vitamin D insufficiency and clinical outcomes of patients with COVID-19 infection |
title_full_unstemmed | Lack of association between vitamin D insufficiency and clinical outcomes of patients with COVID-19 infection |
title_short | Lack of association between vitamin D insufficiency and clinical outcomes of patients with COVID-19 infection |
title_sort | lack of association between vitamin d insufficiency and clinical outcomes of patients with covid-19 infection |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130780/ https://www.ncbi.nlm.nih.gov/pubmed/34006228 http://dx.doi.org/10.1186/s12879-021-06168-7 |
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