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Emerging point-of-care biosensors for rapid diagnosis of COVID-19: current progress, challenges, and future prospects

Coronavirus disease 2019 (COVID-19) pandemic is currently a serious global health threat. While conventional laboratory tests such as quantitative real-time polymerase chain reaction (qPCR), serology tests, and chest computerized tomography (CT) scan allow diagnosis of COVID-19, these tests are time...

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Autores principales: Rasmi, Yousef, Li, Xiaokang, Khan, Johra, Ozer, Tugba, Choi, Jane Ru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130795/
https://www.ncbi.nlm.nih.gov/pubmed/34008124
http://dx.doi.org/10.1007/s00216-021-03377-6
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author Rasmi, Yousef
Li, Xiaokang
Khan, Johra
Ozer, Tugba
Choi, Jane Ru
author_facet Rasmi, Yousef
Li, Xiaokang
Khan, Johra
Ozer, Tugba
Choi, Jane Ru
author_sort Rasmi, Yousef
collection PubMed
description Coronavirus disease 2019 (COVID-19) pandemic is currently a serious global health threat. While conventional laboratory tests such as quantitative real-time polymerase chain reaction (qPCR), serology tests, and chest computerized tomography (CT) scan allow diagnosis of COVID-19, these tests are time-consuming and laborious, and are limited in resource-limited settings or developing countries. Point-of-care (POC) biosensors such as chip-based and paper-based biosensors are typically rapid, portable, cost-effective, and user-friendly, which can be used for COVID-19 in remote settings. The escalating demand for rapid diagnosis of COVID-19 presents a strong need for a timely and comprehensive review on the POC biosensors for COVID-19 that meet ASSURED criteria: Affordable, Sensitive, Specific, User-friendly, Rapid and Robust, Equipment-free, and Deliverable to end users. In the present review, we discuss the importance of rapid and early diagnosis of COVID-19 and pathogenesis of COVID-19 along with the key diagnostic biomarkers. We critically review the most recent advances in POC biosensors which show great promise for the detection of COVID-19 based on three main categories: chip-based biosensors, paper-based biosensors, and other biosensors. We subsequently discuss the key benefits of these biosensors and their use for the detection of antigen, antibody, and viral nucleic acids. The commercial POC biosensors for COVID-19 are critically compared. Finally, we discuss the key challenges and future perspectives of developing emerging POC biosensors for COVID-19. This review would be very useful for guiding strategies for developing and commercializing rapid POC tests to manage the spread of infections. Graphical abstract [Image: see text]
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spelling pubmed-81307952021-05-19 Emerging point-of-care biosensors for rapid diagnosis of COVID-19: current progress, challenges, and future prospects Rasmi, Yousef Li, Xiaokang Khan, Johra Ozer, Tugba Choi, Jane Ru Anal Bioanal Chem Review Coronavirus disease 2019 (COVID-19) pandemic is currently a serious global health threat. While conventional laboratory tests such as quantitative real-time polymerase chain reaction (qPCR), serology tests, and chest computerized tomography (CT) scan allow diagnosis of COVID-19, these tests are time-consuming and laborious, and are limited in resource-limited settings or developing countries. Point-of-care (POC) biosensors such as chip-based and paper-based biosensors are typically rapid, portable, cost-effective, and user-friendly, which can be used for COVID-19 in remote settings. The escalating demand for rapid diagnosis of COVID-19 presents a strong need for a timely and comprehensive review on the POC biosensors for COVID-19 that meet ASSURED criteria: Affordable, Sensitive, Specific, User-friendly, Rapid and Robust, Equipment-free, and Deliverable to end users. In the present review, we discuss the importance of rapid and early diagnosis of COVID-19 and pathogenesis of COVID-19 along with the key diagnostic biomarkers. We critically review the most recent advances in POC biosensors which show great promise for the detection of COVID-19 based on three main categories: chip-based biosensors, paper-based biosensors, and other biosensors. We subsequently discuss the key benefits of these biosensors and their use for the detection of antigen, antibody, and viral nucleic acids. The commercial POC biosensors for COVID-19 are critically compared. Finally, we discuss the key challenges and future perspectives of developing emerging POC biosensors for COVID-19. This review would be very useful for guiding strategies for developing and commercializing rapid POC tests to manage the spread of infections. Graphical abstract [Image: see text] Springer Berlin Heidelberg 2021-05-18 2021 /pmc/articles/PMC8130795/ /pubmed/34008124 http://dx.doi.org/10.1007/s00216-021-03377-6 Text en © Springer-Verlag GmbH Germany, part of Springer Nature 2021 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review
Rasmi, Yousef
Li, Xiaokang
Khan, Johra
Ozer, Tugba
Choi, Jane Ru
Emerging point-of-care biosensors for rapid diagnosis of COVID-19: current progress, challenges, and future prospects
title Emerging point-of-care biosensors for rapid diagnosis of COVID-19: current progress, challenges, and future prospects
title_full Emerging point-of-care biosensors for rapid diagnosis of COVID-19: current progress, challenges, and future prospects
title_fullStr Emerging point-of-care biosensors for rapid diagnosis of COVID-19: current progress, challenges, and future prospects
title_full_unstemmed Emerging point-of-care biosensors for rapid diagnosis of COVID-19: current progress, challenges, and future prospects
title_short Emerging point-of-care biosensors for rapid diagnosis of COVID-19: current progress, challenges, and future prospects
title_sort emerging point-of-care biosensors for rapid diagnosis of covid-19: current progress, challenges, and future prospects
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130795/
https://www.ncbi.nlm.nih.gov/pubmed/34008124
http://dx.doi.org/10.1007/s00216-021-03377-6
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