Induction of Humoral and Cellular Immunity by Intradermal Delivery of SARS-CoV-2 Nucleocapsid Protein Using Dissolvable Microneedles

The nucleocapsid protein (NP) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contains immunogenic epitopes that can induce cytotoxic T lymphocyte (CTL) against viral infection. This makes the nucleocapsid protein a suitable candidate for developing a vaccine against SARS-CoV-2 i...

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Autores principales: Kuwentrai, Chaiyaporn, Yu, Jinming, Zhang, Bao-zhong, Hu, Ye-fan, Dou, Ying, Gong, Hua-rui, Huang, Jian-Dong, Xu, Chenjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130907/
https://www.ncbi.nlm.nih.gov/pubmed/34056008
http://dx.doi.org/10.1155/2021/5531220
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author Kuwentrai, Chaiyaporn
Yu, Jinming
Zhang, Bao-zhong
Hu, Ye-fan
Dou, Ying
Gong, Hua-rui
Huang, Jian-Dong
Xu, Chenjie
author_facet Kuwentrai, Chaiyaporn
Yu, Jinming
Zhang, Bao-zhong
Hu, Ye-fan
Dou, Ying
Gong, Hua-rui
Huang, Jian-Dong
Xu, Chenjie
author_sort Kuwentrai, Chaiyaporn
collection PubMed
description The nucleocapsid protein (NP) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contains immunogenic epitopes that can induce cytotoxic T lymphocyte (CTL) against viral infection. This makes the nucleocapsid protein a suitable candidate for developing a vaccine against SARS-CoV-2 infection. This article reports the intradermal delivery of NP antigen using dissolvable microneedle skin patches that could induce both significant B cell and T cell responses.
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spelling pubmed-81309072021-05-27 Induction of Humoral and Cellular Immunity by Intradermal Delivery of SARS-CoV-2 Nucleocapsid Protein Using Dissolvable Microneedles Kuwentrai, Chaiyaporn Yu, Jinming Zhang, Bao-zhong Hu, Ye-fan Dou, Ying Gong, Hua-rui Huang, Jian-Dong Xu, Chenjie J Immunol Res Research Article The nucleocapsid protein (NP) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contains immunogenic epitopes that can induce cytotoxic T lymphocyte (CTL) against viral infection. This makes the nucleocapsid protein a suitable candidate for developing a vaccine against SARS-CoV-2 infection. This article reports the intradermal delivery of NP antigen using dissolvable microneedle skin patches that could induce both significant B cell and T cell responses. Hindawi 2021-05-17 /pmc/articles/PMC8130907/ /pubmed/34056008 http://dx.doi.org/10.1155/2021/5531220 Text en Copyright © 2021 Chaiyaporn Kuwentrai et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Kuwentrai, Chaiyaporn
Yu, Jinming
Zhang, Bao-zhong
Hu, Ye-fan
Dou, Ying
Gong, Hua-rui
Huang, Jian-Dong
Xu, Chenjie
Induction of Humoral and Cellular Immunity by Intradermal Delivery of SARS-CoV-2 Nucleocapsid Protein Using Dissolvable Microneedles
title Induction of Humoral and Cellular Immunity by Intradermal Delivery of SARS-CoV-2 Nucleocapsid Protein Using Dissolvable Microneedles
title_full Induction of Humoral and Cellular Immunity by Intradermal Delivery of SARS-CoV-2 Nucleocapsid Protein Using Dissolvable Microneedles
title_fullStr Induction of Humoral and Cellular Immunity by Intradermal Delivery of SARS-CoV-2 Nucleocapsid Protein Using Dissolvable Microneedles
title_full_unstemmed Induction of Humoral and Cellular Immunity by Intradermal Delivery of SARS-CoV-2 Nucleocapsid Protein Using Dissolvable Microneedles
title_short Induction of Humoral and Cellular Immunity by Intradermal Delivery of SARS-CoV-2 Nucleocapsid Protein Using Dissolvable Microneedles
title_sort induction of humoral and cellular immunity by intradermal delivery of sars-cov-2 nucleocapsid protein using dissolvable microneedles
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130907/
https://www.ncbi.nlm.nih.gov/pubmed/34056008
http://dx.doi.org/10.1155/2021/5531220
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