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QPLOT Neurons—Converging on a Thermoregulatory Preoptic Neuronal Population

The preoptic area of the hypothalamus is a homeostatic control center. The heterogeneous neurons in this nucleus function to regulate the sleep/wake cycle, reproduction, thirst and hydration, as well as thermogenesis and other metabolic responses. Several recent studies have analyzed preoptic neuron...

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Autores principales: Upton, Brian A., D’Souza, Shane P., Lang, Richard A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130930/
https://www.ncbi.nlm.nih.gov/pubmed/34017237
http://dx.doi.org/10.3389/fnins.2021.665762
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author Upton, Brian A.
D’Souza, Shane P.
Lang, Richard A.
author_facet Upton, Brian A.
D’Souza, Shane P.
Lang, Richard A.
author_sort Upton, Brian A.
collection PubMed
description The preoptic area of the hypothalamus is a homeostatic control center. The heterogeneous neurons in this nucleus function to regulate the sleep/wake cycle, reproduction, thirst and hydration, as well as thermogenesis and other metabolic responses. Several recent studies have analyzed preoptic neuronal populations and demonstrated neuronal subtype-specific roles in suppression of thermogenesis. These studies showed similar thermogenesis responses to chemogenetic modulation, and similar synaptic tracing patterns for neurons that were responsive to cold, to inflammatory stimuli, and to violet light. A reanalysis of single-cell/nucleus RNA-sequencing datasets of the preoptic nucleus indicate that these studies have converged on a common neuronal population that when activated, are sufficient to suppress thermogenesis. Expanding on a previous name for these neurons (Q neurons, which reflect their ability to promote quiescence and expression of Qrfp), we propose a new name: QPLOT neurons, to reflect numerous molecular markers of this population and to capture its broader roles in metabolic regulation. Here, we summarize previous findings on this population and present a unified description of QPLOT neurons, the excitatory preoptic neuronal population that integrate a variety of thermal, metabolic, hormonal and environmental stimuli in order to regulate metabolism and thermogenesis.
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spelling pubmed-81309302021-05-19 QPLOT Neurons—Converging on a Thermoregulatory Preoptic Neuronal Population Upton, Brian A. D’Souza, Shane P. Lang, Richard A. Front Neurosci Neuroscience The preoptic area of the hypothalamus is a homeostatic control center. The heterogeneous neurons in this nucleus function to regulate the sleep/wake cycle, reproduction, thirst and hydration, as well as thermogenesis and other metabolic responses. Several recent studies have analyzed preoptic neuronal populations and demonstrated neuronal subtype-specific roles in suppression of thermogenesis. These studies showed similar thermogenesis responses to chemogenetic modulation, and similar synaptic tracing patterns for neurons that were responsive to cold, to inflammatory stimuli, and to violet light. A reanalysis of single-cell/nucleus RNA-sequencing datasets of the preoptic nucleus indicate that these studies have converged on a common neuronal population that when activated, are sufficient to suppress thermogenesis. Expanding on a previous name for these neurons (Q neurons, which reflect their ability to promote quiescence and expression of Qrfp), we propose a new name: QPLOT neurons, to reflect numerous molecular markers of this population and to capture its broader roles in metabolic regulation. Here, we summarize previous findings on this population and present a unified description of QPLOT neurons, the excitatory preoptic neuronal population that integrate a variety of thermal, metabolic, hormonal and environmental stimuli in order to regulate metabolism and thermogenesis. Frontiers Media S.A. 2021-05-04 /pmc/articles/PMC8130930/ /pubmed/34017237 http://dx.doi.org/10.3389/fnins.2021.665762 Text en Copyright © 2021 Upton, D’Souza and Lang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Upton, Brian A.
D’Souza, Shane P.
Lang, Richard A.
QPLOT Neurons—Converging on a Thermoregulatory Preoptic Neuronal Population
title QPLOT Neurons—Converging on a Thermoregulatory Preoptic Neuronal Population
title_full QPLOT Neurons—Converging on a Thermoregulatory Preoptic Neuronal Population
title_fullStr QPLOT Neurons—Converging on a Thermoregulatory Preoptic Neuronal Population
title_full_unstemmed QPLOT Neurons—Converging on a Thermoregulatory Preoptic Neuronal Population
title_short QPLOT Neurons—Converging on a Thermoregulatory Preoptic Neuronal Population
title_sort qplot neurons—converging on a thermoregulatory preoptic neuronal population
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130930/
https://www.ncbi.nlm.nih.gov/pubmed/34017237
http://dx.doi.org/10.3389/fnins.2021.665762
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