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Clinical characteristics and laboratory features of COVID-19 in high altitude areas: A retrospective cohort study

Coronavirus disease 2019 (COVID-19) is highly contagious and has affected the whole world. We seek to investigate the clinical and laboratory characteristics of COVID-19 patients in the high altitude areas of Sichuan, China. In this retrospective cohort study, a total of 67 patients with laboratory-...

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Autores principales: Chen, Hanxiao, Qin, Lang, Wu, Sixian, Xu, Wenming, Gao, Rui, Zhang, Xiaohong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130933/
https://www.ncbi.nlm.nih.gov/pubmed/34003821
http://dx.doi.org/10.1371/journal.pone.0249964
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author Chen, Hanxiao
Qin, Lang
Wu, Sixian
Xu, Wenming
Gao, Rui
Zhang, Xiaohong
author_facet Chen, Hanxiao
Qin, Lang
Wu, Sixian
Xu, Wenming
Gao, Rui
Zhang, Xiaohong
author_sort Chen, Hanxiao
collection PubMed
description Coronavirus disease 2019 (COVID-19) is highly contagious and has affected the whole world. We seek to investigate the clinical and laboratory characteristics of COVID-19 patients in the high altitude areas of Sichuan, China. In this retrospective cohort study, a total of 67 patients with laboratory-confirmed SARS-CoV-2 infections in Sichuan’s Ngawa Tibetan and Qiang Autonomous Prefecture were included from February 1, 2020, to March 2, 2020. Their clinical characteristics, as well as radiological and laboratory features, were extracted. Four (6.0%) patients were categorized as severe cases; 39 (58.2%) were non-severe cases, and 24 (35.8%) were asymptomatic cases. A total of 46 (68.7%) patients were associated with cluster infection events in this study. The most common symptoms were cough, sputum production, dyspnea, fatigue or myalgia, and headache. Seven (10.4%) patients showed leucopenia, and 20 (29.9%) patients showed lymphopenia. Lymphocyte counts and neutrophil-to-lymphocyte ratios (NPR) were different between the three groups. In total, 14 (20.9%) patients had thrombocytopenia, and prothrombin times (PT) and fibrinogen levels differed between groups. We also found significant differences in sodium, chloride and calcium levels between the three groups. Antiviral therapy did not lead to obvious adverse events or shortened durations from initial positive to subsequent negative nuclei acid tests. Advanced age, hypertension, high neutrophil count, the neutrophil-to-lymphocyte ratio, fibrinogen and lactate dehydrogenase levels were identified as independent risk factors for symptomatic cases of COVID-19. In conclusion, the symptoms of patients in high altitude areas were mild, and about one third were asymptomatic. We also identified several independent risk factors for symptomatic cases of COVID-19.
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spelling pubmed-81309332021-05-27 Clinical characteristics and laboratory features of COVID-19 in high altitude areas: A retrospective cohort study Chen, Hanxiao Qin, Lang Wu, Sixian Xu, Wenming Gao, Rui Zhang, Xiaohong PLoS One Research Article Coronavirus disease 2019 (COVID-19) is highly contagious and has affected the whole world. We seek to investigate the clinical and laboratory characteristics of COVID-19 patients in the high altitude areas of Sichuan, China. In this retrospective cohort study, a total of 67 patients with laboratory-confirmed SARS-CoV-2 infections in Sichuan’s Ngawa Tibetan and Qiang Autonomous Prefecture were included from February 1, 2020, to March 2, 2020. Their clinical characteristics, as well as radiological and laboratory features, were extracted. Four (6.0%) patients were categorized as severe cases; 39 (58.2%) were non-severe cases, and 24 (35.8%) were asymptomatic cases. A total of 46 (68.7%) patients were associated with cluster infection events in this study. The most common symptoms were cough, sputum production, dyspnea, fatigue or myalgia, and headache. Seven (10.4%) patients showed leucopenia, and 20 (29.9%) patients showed lymphopenia. Lymphocyte counts and neutrophil-to-lymphocyte ratios (NPR) were different between the three groups. In total, 14 (20.9%) patients had thrombocytopenia, and prothrombin times (PT) and fibrinogen levels differed between groups. We also found significant differences in sodium, chloride and calcium levels between the three groups. Antiviral therapy did not lead to obvious adverse events or shortened durations from initial positive to subsequent negative nuclei acid tests. Advanced age, hypertension, high neutrophil count, the neutrophil-to-lymphocyte ratio, fibrinogen and lactate dehydrogenase levels were identified as independent risk factors for symptomatic cases of COVID-19. In conclusion, the symptoms of patients in high altitude areas were mild, and about one third were asymptomatic. We also identified several independent risk factors for symptomatic cases of COVID-19. Public Library of Science 2021-05-18 /pmc/articles/PMC8130933/ /pubmed/34003821 http://dx.doi.org/10.1371/journal.pone.0249964 Text en © 2021 Chen et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Chen, Hanxiao
Qin, Lang
Wu, Sixian
Xu, Wenming
Gao, Rui
Zhang, Xiaohong
Clinical characteristics and laboratory features of COVID-19 in high altitude areas: A retrospective cohort study
title Clinical characteristics and laboratory features of COVID-19 in high altitude areas: A retrospective cohort study
title_full Clinical characteristics and laboratory features of COVID-19 in high altitude areas: A retrospective cohort study
title_fullStr Clinical characteristics and laboratory features of COVID-19 in high altitude areas: A retrospective cohort study
title_full_unstemmed Clinical characteristics and laboratory features of COVID-19 in high altitude areas: A retrospective cohort study
title_short Clinical characteristics and laboratory features of COVID-19 in high altitude areas: A retrospective cohort study
title_sort clinical characteristics and laboratory features of covid-19 in high altitude areas: a retrospective cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8130933/
https://www.ncbi.nlm.nih.gov/pubmed/34003821
http://dx.doi.org/10.1371/journal.pone.0249964
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