COVID-19 and the Microbiome: The Gut-Lung Connection

The world is currently experiencing a major pandemic due to COVID-19, a disease caused by SARS-CoV-2 infection. This virus is highly transmissible and clinically presents with a wide range of manifestations. The microbiome has a profound effect on the development of host immunity and susceptibility...

Descripción completa

Detalles Bibliográficos
Autores principales: Aan, Femke J., Glibetic, Natalija, Montoya-Uribe, Vanessa, Matter, Michelle L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131000/
http://dx.doi.org/10.1016/B978-0-12-819265-8.00048-6
_version_ 1783694626757017600
author Aan, Femke J.
Glibetic, Natalija
Montoya-Uribe, Vanessa
Matter, Michelle L.
author_facet Aan, Femke J.
Glibetic, Natalija
Montoya-Uribe, Vanessa
Matter, Michelle L.
author_sort Aan, Femke J.
collection PubMed
description The world is currently experiencing a major pandemic due to COVID-19, a disease caused by SARS-CoV-2 infection. This virus is highly transmissible and clinically presents with a wide range of manifestations. The microbiome has a profound effect on the development of host immunity and susceptibility to infection. In severe COVID-19 patients, alterations of the gut and lung microbiome were detected. Emerging evidence indicates bidirectional crosstalk through a gut-lung axis, in which microbial metabolites, such as short-chain fatty acids, play pivotal roles in human health. In this review we will discuss the gut and lung microbiome in health and during viral infection, with a focus on SARS-CoV-2 infection.
format Online
Article
Text
id pubmed-8131000
institution National Center for Biotechnology Information
language English
publishDate 2022
record_format MEDLINE/PubMed
spelling pubmed-81310002021-05-19 COVID-19 and the Microbiome: The Gut-Lung Connection Aan, Femke J. Glibetic, Natalija Montoya-Uribe, Vanessa Matter, Michelle L. Comprehensive Gut Microbiota Article The world is currently experiencing a major pandemic due to COVID-19, a disease caused by SARS-CoV-2 infection. This virus is highly transmissible and clinically presents with a wide range of manifestations. The microbiome has a profound effect on the development of host immunity and susceptibility to infection. In severe COVID-19 patients, alterations of the gut and lung microbiome were detected. Emerging evidence indicates bidirectional crosstalk through a gut-lung axis, in which microbial metabolites, such as short-chain fatty acids, play pivotal roles in human health. In this review we will discuss the gut and lung microbiome in health and during viral infection, with a focus on SARS-CoV-2 infection. 2022 2022-01-13 /pmc/articles/PMC8131000/ http://dx.doi.org/10.1016/B978-0-12-819265-8.00048-6 Text en Copyright © 2022 Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Aan, Femke J.
Glibetic, Natalija
Montoya-Uribe, Vanessa
Matter, Michelle L.
COVID-19 and the Microbiome: The Gut-Lung Connection
title COVID-19 and the Microbiome: The Gut-Lung Connection
title_full COVID-19 and the Microbiome: The Gut-Lung Connection
title_fullStr COVID-19 and the Microbiome: The Gut-Lung Connection
title_full_unstemmed COVID-19 and the Microbiome: The Gut-Lung Connection
title_short COVID-19 and the Microbiome: The Gut-Lung Connection
title_sort covid-19 and the microbiome: the gut-lung connection
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131000/
http://dx.doi.org/10.1016/B978-0-12-819265-8.00048-6
work_keys_str_mv AT aanfemkej covid19andthemicrobiomethegutlungconnection
AT glibeticnatalija covid19andthemicrobiomethegutlungconnection
AT montoyauribevanessa covid19andthemicrobiomethegutlungconnection
AT mattermichellel covid19andthemicrobiomethegutlungconnection

Ejemplares similares