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Cryptotanshinone, a novel PDK 4 inhibitor, suppresses bladder cancer cell invasiveness via the mTOR/β-catenin/N-cadherin axis

The phosphorylation of pyruvate dehydrogenase (PDH) by pyruvate dehydrogenase kinase (PDK) 4 inhibits its ability to induce a glycolytic shift. PDK4 expression is upregulated in various types of human cancer. Because PDK4 regulation is critical for metabolic changes in cancer cells, it is an attract...

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Detalles Bibliográficos
Autores principales:	Kim, Chul Jang, Terado, Tokio, Tambe, Yukihiro, Mukaisho, Ken-Ichi, Kageyama, Susumu, Kawauchi, Akihiro, Inoue, Hirokazu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2021
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131085/ https://www.ncbi.nlm.nih.gov/pubmed/33982789 http://dx.doi.org/10.3892/ijo.2021.5220

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