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Cutaneous and ocular rosacea: Common and specific physiopathogenic mechanisms and study models
Rosacea is a chronic inflammatory disease that affects the face skin. It is clinically classified into the following four subgroups depending on its location and severity: erythematotelangiectatic, papulopustular, phymatous, and ocular. Rosacea is a multifactorial disease triggered by favoring facto...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Molecular Vision
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131178/ https://www.ncbi.nlm.nih.gov/pubmed/34035646 |
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author | Rodrigues-Braz, Daniela Zhao, Min Yesilirmak, Nilufer Aractingi, Selim Behar-Cohen, Francine Bourges, Jean-Louis |
author_facet | Rodrigues-Braz, Daniela Zhao, Min Yesilirmak, Nilufer Aractingi, Selim Behar-Cohen, Francine Bourges, Jean-Louis |
author_sort | Rodrigues-Braz, Daniela |
collection | PubMed |
description | Rosacea is a chronic inflammatory disease that affects the face skin. It is clinically classified into the following four subgroups depending on its location and severity: erythematotelangiectatic, papulopustular, phymatous, and ocular. Rosacea is a multifactorial disease triggered by favoring factors, the pathogenesis of which remains imperfectly understood. Recognized mechanisms include the innate immune system, with the implication of Toll-like receptors (TLRs) and cathelicidins; neurovascular deregulation involving vascular endothelial growth factor (VEGF), transient receptor potential (TRP) ion channels, and neuropeptides; and dysfunction of skin sebaceous glands and ocular meibomian glands. Microorganisms, genetic predisposition, corticosteroid treatment, and ultraviolet B (UVB) radiation are favoring factors. In this paper, we review the common and specific molecular mechanisms involved in the pathogenesis of cutaneous and ocular rosacea and discuss laboratory and clinical studies, as well as experimental models. |
format | Online Article Text |
id | pubmed-8131178 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Molecular Vision |
record_format | MEDLINE/PubMed |
spelling | pubmed-81311782021-05-24 Cutaneous and ocular rosacea: Common and specific physiopathogenic mechanisms and study models Rodrigues-Braz, Daniela Zhao, Min Yesilirmak, Nilufer Aractingi, Selim Behar-Cohen, Francine Bourges, Jean-Louis Mol Vis Review Rosacea is a chronic inflammatory disease that affects the face skin. It is clinically classified into the following four subgroups depending on its location and severity: erythematotelangiectatic, papulopustular, phymatous, and ocular. Rosacea is a multifactorial disease triggered by favoring factors, the pathogenesis of which remains imperfectly understood. Recognized mechanisms include the innate immune system, with the implication of Toll-like receptors (TLRs) and cathelicidins; neurovascular deregulation involving vascular endothelial growth factor (VEGF), transient receptor potential (TRP) ion channels, and neuropeptides; and dysfunction of skin sebaceous glands and ocular meibomian glands. Microorganisms, genetic predisposition, corticosteroid treatment, and ultraviolet B (UVB) radiation are favoring factors. In this paper, we review the common and specific molecular mechanisms involved in the pathogenesis of cutaneous and ocular rosacea and discuss laboratory and clinical studies, as well as experimental models. Molecular Vision 2021-05-13 /pmc/articles/PMC8131178/ /pubmed/34035646 Text en Copyright © 2021 Molecular Vision. https://creativecommons.org/licenses/by-nc-nd/3.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited, used for non-commercial purposes, and is not altered or transformed. |
spellingShingle | Review Rodrigues-Braz, Daniela Zhao, Min Yesilirmak, Nilufer Aractingi, Selim Behar-Cohen, Francine Bourges, Jean-Louis Cutaneous and ocular rosacea: Common and specific physiopathogenic mechanisms and study models |
title | Cutaneous and ocular rosacea: Common and specific physiopathogenic mechanisms and study models |
title_full | Cutaneous and ocular rosacea: Common and specific physiopathogenic mechanisms and study models |
title_fullStr | Cutaneous and ocular rosacea: Common and specific physiopathogenic mechanisms and study models |
title_full_unstemmed | Cutaneous and ocular rosacea: Common and specific physiopathogenic mechanisms and study models |
title_short | Cutaneous and ocular rosacea: Common and specific physiopathogenic mechanisms and study models |
title_sort | cutaneous and ocular rosacea: common and specific physiopathogenic mechanisms and study models |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131178/ https://www.ncbi.nlm.nih.gov/pubmed/34035646 |
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