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Cutaneous and ocular rosacea: Common and specific physiopathogenic mechanisms and study models

Rosacea is a chronic inflammatory disease that affects the face skin. It is clinically classified into the following four subgroups depending on its location and severity: erythematotelangiectatic, papulopustular, phymatous, and ocular. Rosacea is a multifactorial disease triggered by favoring facto...

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Autores principales: Rodrigues-Braz, Daniela, Zhao, Min, Yesilirmak, Nilufer, Aractingi, Selim, Behar-Cohen, Francine, Bourges, Jean-Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Vision 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131178/
https://www.ncbi.nlm.nih.gov/pubmed/34035646
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author Rodrigues-Braz, Daniela
Zhao, Min
Yesilirmak, Nilufer
Aractingi, Selim
Behar-Cohen, Francine
Bourges, Jean-Louis
author_facet Rodrigues-Braz, Daniela
Zhao, Min
Yesilirmak, Nilufer
Aractingi, Selim
Behar-Cohen, Francine
Bourges, Jean-Louis
author_sort Rodrigues-Braz, Daniela
collection PubMed
description Rosacea is a chronic inflammatory disease that affects the face skin. It is clinically classified into the following four subgroups depending on its location and severity: erythematotelangiectatic, papulopustular, phymatous, and ocular. Rosacea is a multifactorial disease triggered by favoring factors, the pathogenesis of which remains imperfectly understood. Recognized mechanisms include the innate immune system, with the implication of Toll-like receptors (TLRs) and cathelicidins; neurovascular deregulation involving vascular endothelial growth factor (VEGF), transient receptor potential (TRP) ion channels, and neuropeptides; and dysfunction of skin sebaceous glands and ocular meibomian glands. Microorganisms, genetic predisposition, corticosteroid treatment, and ultraviolet B (UVB) radiation are favoring factors. In this paper, we review the common and specific molecular mechanisms involved in the pathogenesis of cutaneous and ocular rosacea and discuss laboratory and clinical studies, as well as experimental models.
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spelling pubmed-81311782021-05-24 Cutaneous and ocular rosacea: Common and specific physiopathogenic mechanisms and study models Rodrigues-Braz, Daniela Zhao, Min Yesilirmak, Nilufer Aractingi, Selim Behar-Cohen, Francine Bourges, Jean-Louis Mol Vis Review Rosacea is a chronic inflammatory disease that affects the face skin. It is clinically classified into the following four subgroups depending on its location and severity: erythematotelangiectatic, papulopustular, phymatous, and ocular. Rosacea is a multifactorial disease triggered by favoring factors, the pathogenesis of which remains imperfectly understood. Recognized mechanisms include the innate immune system, with the implication of Toll-like receptors (TLRs) and cathelicidins; neurovascular deregulation involving vascular endothelial growth factor (VEGF), transient receptor potential (TRP) ion channels, and neuropeptides; and dysfunction of skin sebaceous glands and ocular meibomian glands. Microorganisms, genetic predisposition, corticosteroid treatment, and ultraviolet B (UVB) radiation are favoring factors. In this paper, we review the common and specific molecular mechanisms involved in the pathogenesis of cutaneous and ocular rosacea and discuss laboratory and clinical studies, as well as experimental models. Molecular Vision 2021-05-13 /pmc/articles/PMC8131178/ /pubmed/34035646 Text en Copyright © 2021 Molecular Vision. https://creativecommons.org/licenses/by-nc-nd/3.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited, used for non-commercial purposes, and is not altered or transformed.
spellingShingle Review
Rodrigues-Braz, Daniela
Zhao, Min
Yesilirmak, Nilufer
Aractingi, Selim
Behar-Cohen, Francine
Bourges, Jean-Louis
Cutaneous and ocular rosacea: Common and specific physiopathogenic mechanisms and study models
title Cutaneous and ocular rosacea: Common and specific physiopathogenic mechanisms and study models
title_full Cutaneous and ocular rosacea: Common and specific physiopathogenic mechanisms and study models
title_fullStr Cutaneous and ocular rosacea: Common and specific physiopathogenic mechanisms and study models
title_full_unstemmed Cutaneous and ocular rosacea: Common and specific physiopathogenic mechanisms and study models
title_short Cutaneous and ocular rosacea: Common and specific physiopathogenic mechanisms and study models
title_sort cutaneous and ocular rosacea: common and specific physiopathogenic mechanisms and study models
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131178/
https://www.ncbi.nlm.nih.gov/pubmed/34035646
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