Pathogen-specific antimicrobials engineered de novo through membrane-protein biomimicry

Precision antimicrobials aim to kill pathogens without damaging commensal bacteria in the host, and thus to cure disease without antibiotic-associated dysbiosis. Here, we report the de novo design of a synthetic host defence peptide that targets a specific pathogen by mimicking key molecular feature...

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Detalles Bibliográficos
Autores principales: Simonson, Andrew W., Mongia, Agustey S., Aronson, Matthew R., Alumasa, John N., Chan, Dennis C., Lawanprasert, Atip, Howe, Michael D., Bolotsky, Adam, Mal, Tapas K., George, Christy, Ebrahimi, Aida, Baughn, Anthony D., Proctor, Elizabeth A., Keiler, Kenneth C., Medina, Scott H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131206/
https://www.ncbi.nlm.nih.gov/pubmed/33390588
http://dx.doi.org/10.1038/s41551-020-00665-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131206/
https://www.ncbi.nlm.nih.gov/pubmed/33390588
http://dx.doi.org/10.1038/s41551-020-00665-x

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