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Pathogen-specific antimicrobials engineered de novo through membrane-protein biomimicry
Precision antimicrobials aim to kill pathogens without damaging commensal bacteria in the host, and thus to cure disease without antibiotic-associated dysbiosis. Here, we report the de novo design of a synthetic host defence peptide that targets a specific pathogen by mimicking key molecular feature...
| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131206/ https://www.ncbi.nlm.nih.gov/pubmed/33390588 http://dx.doi.org/10.1038/s41551-020-00665-x |