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Anti-inflammatory effects of FS48, the first potassium channel inhibitor from the salivary glands of the flea Xenopsylla cheopis

The voltage-gated potassium (Kv) 1.3 channel plays a crucial role in the immune responsiveness of T-lymphocytes and macrophages, presenting a potential target for treatment of immune- and inflammation related-diseases. FS48, a protein from the rodent flea Xenopsylla cheopis, shares the three disulfi...

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Detalles Bibliográficos
Autores principales: Deng, Zhenhui, Zeng, Qingye, Tang, Jie, Zhang, Bei, Chai, Jinwei, Andersen, John F., Chen, Xin, Xu, Xueqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131326/
https://www.ncbi.nlm.nih.gov/pubmed/33864815
http://dx.doi.org/10.1016/j.jbc.2021.100670