16p11.2 deletion is associated with hyperactivation of human iPSC-derived dopaminergic neuron networks and is rescued by RHOA inhibition in vitro

Reciprocal copy number variations (CNVs) of 16p11.2 are associated with a wide spectrum of neuropsychiatric and neurodevelopmental disorders. Here, we use human induced pluripotent stem cells (iPSCs)-derived dopaminergic (DA) neurons carrying CNVs of 16p11.2 duplication (16pdup) and 16p11.2 deletion...

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Detalles Bibliográficos
Autores principales: Sundberg, Maria, Pinson, Hannah, Smith, Richard S., Winden, Kellen D., Venugopal, Pooja, Tai, Derek J. C., Gusella, James F., Talkowski, Michael E., Walsh, Christopher A., Tegmark, Max, Sahin, Mustafa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131375/
https://www.ncbi.nlm.nih.gov/pubmed/34006844
http://dx.doi.org/10.1038/s41467-021-23113-z

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