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Neuroendocrine carcinoma of the gallbladder concomitant with adenocarcinoma of the sigmoid colon: A rare case report

INTRODUCTION AND IMPORTANCE: Neuroendocrine carcinoma of the gallbladder is rare and aggressive, its diagnosis is based on pathologic and immunohistochemical examination, currently there is no standard treatment for this tumor. Its concomitant occurrence with adenocarcinoma of the sigmoid colon is e...

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Autores principales: Chablou, Mohamed, Mabrouk, Yassine, Maamar, Khalil, Jabi, Rachid, Bouziane, Mohammed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131395/
https://www.ncbi.nlm.nih.gov/pubmed/34026109
http://dx.doi.org/10.1016/j.amsu.2021.102359
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author Chablou, Mohamed
Mabrouk, Yassine
Maamar, Khalil
Jabi, Rachid
Bouziane, Mohammed
author_facet Chablou, Mohamed
Mabrouk, Yassine
Maamar, Khalil
Jabi, Rachid
Bouziane, Mohammed
author_sort Chablou, Mohamed
collection PubMed
description INTRODUCTION AND IMPORTANCE: Neuroendocrine carcinoma of the gallbladder is rare and aggressive, its diagnosis is based on pathologic and immunohistochemical examination, currently there is no standard treatment for this tumor. Its concomitant occurrence with adenocarcinoma of the sigmoid colon is exceptional. CASE PRESENTATION: This case report describes a rare case of neuroendocrine carcinoma of the gallbladder that occurred concomitantly with sigmoid colon adenocarcinoma. The diagnosis of neuroendocrine carcinoma was established postoperatively by pathological and immunohistochemical examination. The biopsy of the colonic process confirmed the preoperative diagnosis. A laparotomy found a vesicular fundus process, peri-hilar adenopathy, metastasis of the liver segment V, and a sigmoid colon process. The patient underwent a cholecystectomy extended to segments IVb and V, with lymph node dissection and sigmoid colectomy. The postoperative follow-up was uneventful, and the length of hospitalization was seven days. The patient is currently undergoing adjuvant chemotherapy. DISCUSSION: Neuroendocrine carcinoma of the gallbladder is extremely rare, with few case reports, its occurrence concomitantly with adenocarcinoma of the sigmoid colon is exceptional. Histology and immunohistochemistry confirm the diagnosis, surgery is essential in the management of patients affected by this tumor. The presence of synchronous metastases causes doubt about their primitive, hence the primordial place of surgery and histological examination to adopt adequate management of the patients. CONCLUSION: We underline the rarity of this neuroendocrine tumor and the importance of histology and surgery in its management.
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spelling pubmed-81313952021-05-21 Neuroendocrine carcinoma of the gallbladder concomitant with adenocarcinoma of the sigmoid colon: A rare case report Chablou, Mohamed Mabrouk, Yassine Maamar, Khalil Jabi, Rachid Bouziane, Mohammed Ann Med Surg (Lond) Case Report INTRODUCTION AND IMPORTANCE: Neuroendocrine carcinoma of the gallbladder is rare and aggressive, its diagnosis is based on pathologic and immunohistochemical examination, currently there is no standard treatment for this tumor. Its concomitant occurrence with adenocarcinoma of the sigmoid colon is exceptional. CASE PRESENTATION: This case report describes a rare case of neuroendocrine carcinoma of the gallbladder that occurred concomitantly with sigmoid colon adenocarcinoma. The diagnosis of neuroendocrine carcinoma was established postoperatively by pathological and immunohistochemical examination. The biopsy of the colonic process confirmed the preoperative diagnosis. A laparotomy found a vesicular fundus process, peri-hilar adenopathy, metastasis of the liver segment V, and a sigmoid colon process. The patient underwent a cholecystectomy extended to segments IVb and V, with lymph node dissection and sigmoid colectomy. The postoperative follow-up was uneventful, and the length of hospitalization was seven days. The patient is currently undergoing adjuvant chemotherapy. DISCUSSION: Neuroendocrine carcinoma of the gallbladder is extremely rare, with few case reports, its occurrence concomitantly with adenocarcinoma of the sigmoid colon is exceptional. Histology and immunohistochemistry confirm the diagnosis, surgery is essential in the management of patients affected by this tumor. The presence of synchronous metastases causes doubt about their primitive, hence the primordial place of surgery and histological examination to adopt adequate management of the patients. CONCLUSION: We underline the rarity of this neuroendocrine tumor and the importance of histology and surgery in its management. Elsevier 2021-05-06 /pmc/articles/PMC8131395/ /pubmed/34026109 http://dx.doi.org/10.1016/j.amsu.2021.102359 Text en © 2021 The Authors. Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Chablou, Mohamed
Mabrouk, Yassine
Maamar, Khalil
Jabi, Rachid
Bouziane, Mohammed
Neuroendocrine carcinoma of the gallbladder concomitant with adenocarcinoma of the sigmoid colon: A rare case report
title Neuroendocrine carcinoma of the gallbladder concomitant with adenocarcinoma of the sigmoid colon: A rare case report
title_full Neuroendocrine carcinoma of the gallbladder concomitant with adenocarcinoma of the sigmoid colon: A rare case report
title_fullStr Neuroendocrine carcinoma of the gallbladder concomitant with adenocarcinoma of the sigmoid colon: A rare case report
title_full_unstemmed Neuroendocrine carcinoma of the gallbladder concomitant with adenocarcinoma of the sigmoid colon: A rare case report
title_short Neuroendocrine carcinoma of the gallbladder concomitant with adenocarcinoma of the sigmoid colon: A rare case report
title_sort neuroendocrine carcinoma of the gallbladder concomitant with adenocarcinoma of the sigmoid colon: a rare case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131395/
https://www.ncbi.nlm.nih.gov/pubmed/34026109
http://dx.doi.org/10.1016/j.amsu.2021.102359
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