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Burden of critically ill patients with influenza in a French catchment population
Despite the particular focus given to influenza since the 2009 influenza A(H1N1) pandemic, true burden of influenza-associated critical illness remains poorly known. The aim of this study was to identify factors influencing influenza burden imposed on intensive care units (ICUs) in a catchment popul...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131583/ https://www.ncbi.nlm.nih.gov/pubmed/34006932 http://dx.doi.org/10.1038/s41598-021-89912-y |
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author | Hernu, Romain Simon, Marie Baudry, Thomas Casalegno, Jean-Sébastien Lina, Bruno Cour, Martin Argaud, Laurent |
author_facet | Hernu, Romain Simon, Marie Baudry, Thomas Casalegno, Jean-Sébastien Lina, Bruno Cour, Martin Argaud, Laurent |
author_sort | Hernu, Romain |
collection | PubMed |
description | Despite the particular focus given to influenza since the 2009 influenza A(H1N1) pandemic, true burden of influenza-associated critical illness remains poorly known. The aim of this study was to identify factors influencing influenza burden imposed on intensive care units (ICUs) in a catchment population during recent influenza seasons. From 2008 to 2013, all adult patients admitted with a laboratory-confirmed influenza infection to one of the ICUs in the catchment area were prospectively included. A total of 201 patients (mean age: 63 ± 16, sex-ratio: 1.1) were included. The influenza-related ICU-bed occupancy rate averaged 4.3% over the five influenza seasons, with the highest mean occupancy rate (16.9%) observed during the 2012 winter. In-hospital mortality for the whole cohort was 26%. Influenza A(H1N1)pdm infections (pdm in the mentioned nomenclature refers to Pandemic Disease Mexico 2009), encountered in 51% of cases, were significantly associated with neither longer length of stay nor higher mortality (ICU and hospital) when compared to infections with other virus subtypes. SOFA score (OR, 1.12; 95% CI, 1.04–1.29) was the only independent factor significantly associated with a prolonged hospitalization. These results highlight both the frequency and the severity of influenza-associated critical illness, leading to a sustained activity in ICUs. Severity of the disease, but not A(H1N1)pdm virus, appears to be a major determinant of ICU burden related to influenza. |
format | Online Article Text |
id | pubmed-8131583 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-81315832021-05-19 Burden of critically ill patients with influenza in a French catchment population Hernu, Romain Simon, Marie Baudry, Thomas Casalegno, Jean-Sébastien Lina, Bruno Cour, Martin Argaud, Laurent Sci Rep Article Despite the particular focus given to influenza since the 2009 influenza A(H1N1) pandemic, true burden of influenza-associated critical illness remains poorly known. The aim of this study was to identify factors influencing influenza burden imposed on intensive care units (ICUs) in a catchment population during recent influenza seasons. From 2008 to 2013, all adult patients admitted with a laboratory-confirmed influenza infection to one of the ICUs in the catchment area were prospectively included. A total of 201 patients (mean age: 63 ± 16, sex-ratio: 1.1) were included. The influenza-related ICU-bed occupancy rate averaged 4.3% over the five influenza seasons, with the highest mean occupancy rate (16.9%) observed during the 2012 winter. In-hospital mortality for the whole cohort was 26%. Influenza A(H1N1)pdm infections (pdm in the mentioned nomenclature refers to Pandemic Disease Mexico 2009), encountered in 51% of cases, were significantly associated with neither longer length of stay nor higher mortality (ICU and hospital) when compared to infections with other virus subtypes. SOFA score (OR, 1.12; 95% CI, 1.04–1.29) was the only independent factor significantly associated with a prolonged hospitalization. These results highlight both the frequency and the severity of influenza-associated critical illness, leading to a sustained activity in ICUs. Severity of the disease, but not A(H1N1)pdm virus, appears to be a major determinant of ICU burden related to influenza. Nature Publishing Group UK 2021-05-18 /pmc/articles/PMC8131583/ /pubmed/34006932 http://dx.doi.org/10.1038/s41598-021-89912-y Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Hernu, Romain Simon, Marie Baudry, Thomas Casalegno, Jean-Sébastien Lina, Bruno Cour, Martin Argaud, Laurent Burden of critically ill patients with influenza in a French catchment population |
title | Burden of critically ill patients with influenza in a French catchment population |
title_full | Burden of critically ill patients with influenza in a French catchment population |
title_fullStr | Burden of critically ill patients with influenza in a French catchment population |
title_full_unstemmed | Burden of critically ill patients with influenza in a French catchment population |
title_short | Burden of critically ill patients with influenza in a French catchment population |
title_sort | burden of critically ill patients with influenza in a french catchment population |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131583/ https://www.ncbi.nlm.nih.gov/pubmed/34006932 http://dx.doi.org/10.1038/s41598-021-89912-y |
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