High glucose suppresses autophagy through the AMPK pathway while it induces autophagy via oxidative stress in chondrocytes

Diabetes (DB) is a risk factor for osteoarthritis progression. High glucose (HG) is one of the key pathological features of DB and has been demonstrated to induce apoptosis and senescence in chondrocytes. Autophagy is an endogenous mechanism that can protect cells against apoptosis and senescence. T...

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Detalles Bibliográficos
Autores principales: Wang, Ben, Shi, Yifeng, Chen, Jiaoxiang, Shao, Zhenxuan, Ni, Libin, Lin, Yan, Wu, Yaosen, Tian, Naifeng, Zhou, Yifei, Sun, Liaojun, Wu, Aimin, Hong, Zhenghua, Wang, Xiangyang, Zhang, Xiaolei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131591/
https://www.ncbi.nlm.nih.gov/pubmed/34006821
http://dx.doi.org/10.1038/s41419-021-03791-9

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