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A deep learning model for detection of cervical spinal cord compression in MRI scans

Magnetic Resonance Imaging (MRI) evidence of spinal cord compression plays a central role in the diagnosis of degenerative cervical myelopathy (DCM). There is growing recognition that deep learning models may assist in addressing the increasing volume of medical imaging data and provide initial inte...

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Autores principales: Merali, Zamir, Wang, Justin Z., Badhiwala, Jetan H., Witiw, Christopher D., Wilson, Jefferson R., Fehlings, Michael G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131597/
https://www.ncbi.nlm.nih.gov/pubmed/34006910
http://dx.doi.org/10.1038/s41598-021-89848-3
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author Merali, Zamir
Wang, Justin Z.
Badhiwala, Jetan H.
Witiw, Christopher D.
Wilson, Jefferson R.
Fehlings, Michael G.
author_facet Merali, Zamir
Wang, Justin Z.
Badhiwala, Jetan H.
Witiw, Christopher D.
Wilson, Jefferson R.
Fehlings, Michael G.
author_sort Merali, Zamir
collection PubMed
description Magnetic Resonance Imaging (MRI) evidence of spinal cord compression plays a central role in the diagnosis of degenerative cervical myelopathy (DCM). There is growing recognition that deep learning models may assist in addressing the increasing volume of medical imaging data and provide initial interpretation of images gathered in a primary-care setting. We aimed to develop and validate a deep learning model for detection of cervical spinal cord compression in MRI scans. Patients undergoing surgery for DCM as a part of the AO Spine CSM-NA or CSM-I prospective cohort studies were included in our study. Patients were divided into a training/validation or holdout dataset. Images were labelled by two specialist physicians. We trained a deep convolutional neural network using images from the training/validation dataset and assessed model performance on the holdout dataset. The training/validation cohort included 201 patients with 6588 images and the holdout dataset included 88 patients with 2991 images. On the holdout dataset the deep learning model achieved an overall AUC of 0.94, sensitivity of 0.88, specificity of 0.89, and f1-score of 0.82. This model could improve the efficiency and objectivity of the interpretation of cervical spine MRI scans.
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spelling pubmed-81315972021-05-19 A deep learning model for detection of cervical spinal cord compression in MRI scans Merali, Zamir Wang, Justin Z. Badhiwala, Jetan H. Witiw, Christopher D. Wilson, Jefferson R. Fehlings, Michael G. Sci Rep Article Magnetic Resonance Imaging (MRI) evidence of spinal cord compression plays a central role in the diagnosis of degenerative cervical myelopathy (DCM). There is growing recognition that deep learning models may assist in addressing the increasing volume of medical imaging data and provide initial interpretation of images gathered in a primary-care setting. We aimed to develop and validate a deep learning model for detection of cervical spinal cord compression in MRI scans. Patients undergoing surgery for DCM as a part of the AO Spine CSM-NA or CSM-I prospective cohort studies were included in our study. Patients were divided into a training/validation or holdout dataset. Images were labelled by two specialist physicians. We trained a deep convolutional neural network using images from the training/validation dataset and assessed model performance on the holdout dataset. The training/validation cohort included 201 patients with 6588 images and the holdout dataset included 88 patients with 2991 images. On the holdout dataset the deep learning model achieved an overall AUC of 0.94, sensitivity of 0.88, specificity of 0.89, and f1-score of 0.82. This model could improve the efficiency and objectivity of the interpretation of cervical spine MRI scans. Nature Publishing Group UK 2021-05-18 /pmc/articles/PMC8131597/ /pubmed/34006910 http://dx.doi.org/10.1038/s41598-021-89848-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Merali, Zamir
Wang, Justin Z.
Badhiwala, Jetan H.
Witiw, Christopher D.
Wilson, Jefferson R.
Fehlings, Michael G.
A deep learning model for detection of cervical spinal cord compression in MRI scans
title A deep learning model for detection of cervical spinal cord compression in MRI scans
title_full A deep learning model for detection of cervical spinal cord compression in MRI scans
title_fullStr A deep learning model for detection of cervical spinal cord compression in MRI scans
title_full_unstemmed A deep learning model for detection of cervical spinal cord compression in MRI scans
title_short A deep learning model for detection of cervical spinal cord compression in MRI scans
title_sort deep learning model for detection of cervical spinal cord compression in mri scans
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131597/
https://www.ncbi.nlm.nih.gov/pubmed/34006910
http://dx.doi.org/10.1038/s41598-021-89848-3
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