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Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices
The increased healthspan afforded by coffee intake provides novel opportunities to identify new therapeutic strategies. Caffeine has been proposed to afford benefits through adenosine A(2A) receptors, which can control synaptic dysfunction underlying some brain disease. However, decaffeinated coffee...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131611/ https://www.ncbi.nlm.nih.gov/pubmed/34006978 http://dx.doi.org/10.1038/s41598-021-89964-0 |
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author | Fernandes, Mara Yone D. Dobrachinski, Fernando Silva, Henrique B. Lopes, João Pedro Gonçalves, Francisco Q. Soares, Felix A. A. Porciúncula, Lisiane O. Andrade, Geanne M. Cunha, Rodrigo A. Tomé, Angelo R. |
author_facet | Fernandes, Mara Yone D. Dobrachinski, Fernando Silva, Henrique B. Lopes, João Pedro Gonçalves, Francisco Q. Soares, Felix A. A. Porciúncula, Lisiane O. Andrade, Geanne M. Cunha, Rodrigo A. Tomé, Angelo R. |
author_sort | Fernandes, Mara Yone D. |
collection | PubMed |
description | The increased healthspan afforded by coffee intake provides novel opportunities to identify new therapeutic strategies. Caffeine has been proposed to afford benefits through adenosine A(2A) receptors, which can control synaptic dysfunction underlying some brain disease. However, decaffeinated coffee and other main components of coffee such as chlorogenic acids, also attenuate brain dysfunction, although it is unknown if they control synaptic function. We now used electrophysiological recordings in mouse hippocampal slices to test if realistic concentrations of chlorogenic acids directly affect synaptic transmission and plasticity. 3-(3,4-dihydroxycinnamoyl)quinic acid (CA, 1–10 μM) and 5-O-(trans-3,4-dihydroxycinnamoyl)-D-quinic acid (NCA, 1–10 μM) were devoid of effect on synaptic transmission, paired-pulse facilitation or long-term potentiation (LTP) and long-term depression (LTD) in Schaffer collaterals-CA1 pyramidal synapses. However, CA and NCA increased the recovery of synaptic transmission upon re-oxygenation following 7 min of oxygen/glucose deprivation, an in vitro ischemia model. Also, CA and NCA attenuated the shift of LTD into LTP observed in hippocampal slices from animals with hippocampal-dependent memory deterioration after exposure to β-amyloid 1–42 (2 nmol, icv), in the context of Alzheimer’s disease. These findings show that chlorogenic acids do not directly affect synaptic transmission and plasticity but can indirectly affect other cellular targets to correct synaptic dysfunction. Unraveling the molecular mechanisms of action of chlorogenic acids will allow the design of hitherto unrecognized novel neuroprotective strategies. |
format | Online Article Text |
id | pubmed-8131611 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-81316112021-05-25 Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices Fernandes, Mara Yone D. Dobrachinski, Fernando Silva, Henrique B. Lopes, João Pedro Gonçalves, Francisco Q. Soares, Felix A. A. Porciúncula, Lisiane O. Andrade, Geanne M. Cunha, Rodrigo A. Tomé, Angelo R. Sci Rep Article The increased healthspan afforded by coffee intake provides novel opportunities to identify new therapeutic strategies. Caffeine has been proposed to afford benefits through adenosine A(2A) receptors, which can control synaptic dysfunction underlying some brain disease. However, decaffeinated coffee and other main components of coffee such as chlorogenic acids, also attenuate brain dysfunction, although it is unknown if they control synaptic function. We now used electrophysiological recordings in mouse hippocampal slices to test if realistic concentrations of chlorogenic acids directly affect synaptic transmission and plasticity. 3-(3,4-dihydroxycinnamoyl)quinic acid (CA, 1–10 μM) and 5-O-(trans-3,4-dihydroxycinnamoyl)-D-quinic acid (NCA, 1–10 μM) were devoid of effect on synaptic transmission, paired-pulse facilitation or long-term potentiation (LTP) and long-term depression (LTD) in Schaffer collaterals-CA1 pyramidal synapses. However, CA and NCA increased the recovery of synaptic transmission upon re-oxygenation following 7 min of oxygen/glucose deprivation, an in vitro ischemia model. Also, CA and NCA attenuated the shift of LTD into LTP observed in hippocampal slices from animals with hippocampal-dependent memory deterioration after exposure to β-amyloid 1–42 (2 nmol, icv), in the context of Alzheimer’s disease. These findings show that chlorogenic acids do not directly affect synaptic transmission and plasticity but can indirectly affect other cellular targets to correct synaptic dysfunction. Unraveling the molecular mechanisms of action of chlorogenic acids will allow the design of hitherto unrecognized novel neuroprotective strategies. Nature Publishing Group UK 2021-05-18 /pmc/articles/PMC8131611/ /pubmed/34006978 http://dx.doi.org/10.1038/s41598-021-89964-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Fernandes, Mara Yone D. Dobrachinski, Fernando Silva, Henrique B. Lopes, João Pedro Gonçalves, Francisco Q. Soares, Felix A. A. Porciúncula, Lisiane O. Andrade, Geanne M. Cunha, Rodrigo A. Tomé, Angelo R. Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices |
title | Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices |
title_full | Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices |
title_fullStr | Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices |
title_full_unstemmed | Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices |
title_short | Neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices |
title_sort | neuromodulation and neuroprotective effects of chlorogenic acids in excitatory synapses of mouse hippocampal slices |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131611/ https://www.ncbi.nlm.nih.gov/pubmed/34006978 http://dx.doi.org/10.1038/s41598-021-89964-0 |
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