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Evaluation of Chronic Kidney Disease Progression in Dogs With Therapeutic Management of Risk Factors

This research was performed to describe the characteristics of the progression of naturally occurring chronic kidney disease (CKD) in dogs, together with the management of identified risk factors, following the International Renal Interest Society recommendations. Dogs diagnosed and staged with CKD,...

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Autores principales: Perini-Perera, Sofía, Del-Ángel-Caraza, Javier, Pérez-Sánchez, Alicia Pamela, Quijano-Hernández, Israel Alejandro, Recillas-Morales, Sergio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131674/
https://www.ncbi.nlm.nih.gov/pubmed/34026884
http://dx.doi.org/10.3389/fvets.2021.621084
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author Perini-Perera, Sofía
Del-Ángel-Caraza, Javier
Pérez-Sánchez, Alicia Pamela
Quijano-Hernández, Israel Alejandro
Recillas-Morales, Sergio
author_facet Perini-Perera, Sofía
Del-Ángel-Caraza, Javier
Pérez-Sánchez, Alicia Pamela
Quijano-Hernández, Israel Alejandro
Recillas-Morales, Sergio
author_sort Perini-Perera, Sofía
collection PubMed
description This research was performed to describe the characteristics of the progression of naturally occurring chronic kidney disease (CKD) in dogs, together with the management of identified risk factors, following the International Renal Interest Society recommendations. Dogs diagnosed and staged with CKD, and with a longitudinal follow-up from the moment of diagnosis of up to a maximum of 730 days, were included. A total of 545 dogs that presented risk factors for the development of CKD were analyzed, out of which 36 met the inclusion criteria. Advanced age was identified in 80.6% of cases. Initiation risk factors were represented by inflammatory/infectious diseases, history of anesthetic-surgical procedures, heart disease, neoplasms, endocrinopathies, and exposure to nephrotoxic drugs. During the follow-up period, progression of CKD was identified in 47.2% of the cases, being more salient in advanced stages. Serum symmetric dimethyl arginine (SDMA) was the only glomerular filtration rate (GFR) marker which displayed differences among studied times during early stages of CKD, associated with the disease progression and decline of renal function. A significant difference between the survival curves in early and advanced CKD stages was observed. The factors related to decreased survival were hyperphosphatemia, anemia, and low body condition score (BCS). No differences were found between the presence of arterial hypertension and renal proteinuria and decreased survival. Furthermore, CKD diagnosis based on the persistent finding of abnormalities in early disease markers, such as serum symmetric dimethyl arginine increase and/or renal proteinuria, and timely therapeutic management of risk factors, allowed for CKD stabilization, reducing progression to advanced stages, and favoring higher survival rates.
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spelling pubmed-81316742021-05-20 Evaluation of Chronic Kidney Disease Progression in Dogs With Therapeutic Management of Risk Factors Perini-Perera, Sofía Del-Ángel-Caraza, Javier Pérez-Sánchez, Alicia Pamela Quijano-Hernández, Israel Alejandro Recillas-Morales, Sergio Front Vet Sci Veterinary Science This research was performed to describe the characteristics of the progression of naturally occurring chronic kidney disease (CKD) in dogs, together with the management of identified risk factors, following the International Renal Interest Society recommendations. Dogs diagnosed and staged with CKD, and with a longitudinal follow-up from the moment of diagnosis of up to a maximum of 730 days, were included. A total of 545 dogs that presented risk factors for the development of CKD were analyzed, out of which 36 met the inclusion criteria. Advanced age was identified in 80.6% of cases. Initiation risk factors were represented by inflammatory/infectious diseases, history of anesthetic-surgical procedures, heart disease, neoplasms, endocrinopathies, and exposure to nephrotoxic drugs. During the follow-up period, progression of CKD was identified in 47.2% of the cases, being more salient in advanced stages. Serum symmetric dimethyl arginine (SDMA) was the only glomerular filtration rate (GFR) marker which displayed differences among studied times during early stages of CKD, associated with the disease progression and decline of renal function. A significant difference between the survival curves in early and advanced CKD stages was observed. The factors related to decreased survival were hyperphosphatemia, anemia, and low body condition score (BCS). No differences were found between the presence of arterial hypertension and renal proteinuria and decreased survival. Furthermore, CKD diagnosis based on the persistent finding of abnormalities in early disease markers, such as serum symmetric dimethyl arginine increase and/or renal proteinuria, and timely therapeutic management of risk factors, allowed for CKD stabilization, reducing progression to advanced stages, and favoring higher survival rates. Frontiers Media S.A. 2021-05-05 /pmc/articles/PMC8131674/ /pubmed/34026884 http://dx.doi.org/10.3389/fvets.2021.621084 Text en Copyright © 2021 Perini-Perera, Del-Ángel-Caraza, Pérez-Sánchez, Quijano-Hernández and Recillas-Morales. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Veterinary Science
Perini-Perera, Sofía
Del-Ángel-Caraza, Javier
Pérez-Sánchez, Alicia Pamela
Quijano-Hernández, Israel Alejandro
Recillas-Morales, Sergio
Evaluation of Chronic Kidney Disease Progression in Dogs With Therapeutic Management of Risk Factors
title Evaluation of Chronic Kidney Disease Progression in Dogs With Therapeutic Management of Risk Factors
title_full Evaluation of Chronic Kidney Disease Progression in Dogs With Therapeutic Management of Risk Factors
title_fullStr Evaluation of Chronic Kidney Disease Progression in Dogs With Therapeutic Management of Risk Factors
title_full_unstemmed Evaluation of Chronic Kidney Disease Progression in Dogs With Therapeutic Management of Risk Factors
title_short Evaluation of Chronic Kidney Disease Progression in Dogs With Therapeutic Management of Risk Factors
title_sort evaluation of chronic kidney disease progression in dogs with therapeutic management of risk factors
topic Veterinary Science
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131674/
https://www.ncbi.nlm.nih.gov/pubmed/34026884
http://dx.doi.org/10.3389/fvets.2021.621084
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