Cargando…

The Smad Dependent TGF-β and BMP Signaling Pathway in Bone Remodeling and Therapies

Bone remodeling is a continuous process that maintains the homeostasis of the skeletal system, and it depends on the homeostasis between bone-forming osteoblasts and bone-absorbing osteoclasts. A large number of studies have confirmed that the Smad signaling pathway is essential for the regulation o...

Descripción completa

Detalles Bibliográficos
Autores principales: Zou, Ming-Li, Chen, Zhong-Hua, Teng, Ying-Ying, Liu, Si-Yu, Jia, Yuan, Zhang, Kai-Wen, Sun, Zi-Li, Wu, Jun-Jie, Yuan, Zheng-Dong, Feng, Yi, Li, Xia, Xu, Rui-Sheng, Yuan, Feng-Lai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131681/
https://www.ncbi.nlm.nih.gov/pubmed/34026818
http://dx.doi.org/10.3389/fmolb.2021.593310
_version_ 1783694752297779200
author Zou, Ming-Li
Chen, Zhong-Hua
Teng, Ying-Ying
Liu, Si-Yu
Jia, Yuan
Zhang, Kai-Wen
Sun, Zi-Li
Wu, Jun-Jie
Yuan, Zheng-Dong
Feng, Yi
Li, Xia
Xu, Rui-Sheng
Yuan, Feng-Lai
author_facet Zou, Ming-Li
Chen, Zhong-Hua
Teng, Ying-Ying
Liu, Si-Yu
Jia, Yuan
Zhang, Kai-Wen
Sun, Zi-Li
Wu, Jun-Jie
Yuan, Zheng-Dong
Feng, Yi
Li, Xia
Xu, Rui-Sheng
Yuan, Feng-Lai
author_sort Zou, Ming-Li
collection PubMed
description Bone remodeling is a continuous process that maintains the homeostasis of the skeletal system, and it depends on the homeostasis between bone-forming osteoblasts and bone-absorbing osteoclasts. A large number of studies have confirmed that the Smad signaling pathway is essential for the regulation of osteoblastic and osteoclastic differentiation during skeletal development, bone formation and bone homeostasis, suggesting a close relationship between Smad signaling and bone remodeling. It is known that Smads proteins are pivotal intracellular effectors for the members of the transforming growth factor-β (TGF-β) and bone morphogenetic proteins (BMP), acting as transcription factors. Smad mediates the signal transduction in TGF-β and BMP signaling pathway that affects both osteoblast and osteoclast functions, and therefore plays a critical role in the regulation of bone remodeling. Increasing studies have demonstrated that a number of Smad signaling regulators have potential functions in bone remodeling. Therefore, targeting Smad dependent TGF-β and BMP signaling pathway might be a novel and promising therapeutic strategy against osteoporosis. This article aims to review recent advances in this field, summarizing the influence of Smad on osteoblast and osteoclast function, together with Smad signaling regulators in bone remodeling. This will facilitate the understanding of Smad signaling pathway in bone biology and shed new light on the modulation and potential treatment for osteoporosis.
format Online
Article
Text
id pubmed-8131681
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-81316812021-05-20 The Smad Dependent TGF-β and BMP Signaling Pathway in Bone Remodeling and Therapies Zou, Ming-Li Chen, Zhong-Hua Teng, Ying-Ying Liu, Si-Yu Jia, Yuan Zhang, Kai-Wen Sun, Zi-Li Wu, Jun-Jie Yuan, Zheng-Dong Feng, Yi Li, Xia Xu, Rui-Sheng Yuan, Feng-Lai Front Mol Biosci Molecular Biosciences Bone remodeling is a continuous process that maintains the homeostasis of the skeletal system, and it depends on the homeostasis between bone-forming osteoblasts and bone-absorbing osteoclasts. A large number of studies have confirmed that the Smad signaling pathway is essential for the regulation of osteoblastic and osteoclastic differentiation during skeletal development, bone formation and bone homeostasis, suggesting a close relationship between Smad signaling and bone remodeling. It is known that Smads proteins are pivotal intracellular effectors for the members of the transforming growth factor-β (TGF-β) and bone morphogenetic proteins (BMP), acting as transcription factors. Smad mediates the signal transduction in TGF-β and BMP signaling pathway that affects both osteoblast and osteoclast functions, and therefore plays a critical role in the regulation of bone remodeling. Increasing studies have demonstrated that a number of Smad signaling regulators have potential functions in bone remodeling. Therefore, targeting Smad dependent TGF-β and BMP signaling pathway might be a novel and promising therapeutic strategy against osteoporosis. This article aims to review recent advances in this field, summarizing the influence of Smad on osteoblast and osteoclast function, together with Smad signaling regulators in bone remodeling. This will facilitate the understanding of Smad signaling pathway in bone biology and shed new light on the modulation and potential treatment for osteoporosis. Frontiers Media S.A. 2021-05-05 /pmc/articles/PMC8131681/ /pubmed/34026818 http://dx.doi.org/10.3389/fmolb.2021.593310 Text en Copyright © 2021 Zou, Chen, Teng, Liu, Jia, Zhang, Sun, Wu, Yuan, Feng, Li, Xu and Yuan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Zou, Ming-Li
Chen, Zhong-Hua
Teng, Ying-Ying
Liu, Si-Yu
Jia, Yuan
Zhang, Kai-Wen
Sun, Zi-Li
Wu, Jun-Jie
Yuan, Zheng-Dong
Feng, Yi
Li, Xia
Xu, Rui-Sheng
Yuan, Feng-Lai
The Smad Dependent TGF-β and BMP Signaling Pathway in Bone Remodeling and Therapies
title The Smad Dependent TGF-β and BMP Signaling Pathway in Bone Remodeling and Therapies
title_full The Smad Dependent TGF-β and BMP Signaling Pathway in Bone Remodeling and Therapies
title_fullStr The Smad Dependent TGF-β and BMP Signaling Pathway in Bone Remodeling and Therapies
title_full_unstemmed The Smad Dependent TGF-β and BMP Signaling Pathway in Bone Remodeling and Therapies
title_short The Smad Dependent TGF-β and BMP Signaling Pathway in Bone Remodeling and Therapies
title_sort smad dependent tgf-β and bmp signaling pathway in bone remodeling and therapies
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131681/
https://www.ncbi.nlm.nih.gov/pubmed/34026818
http://dx.doi.org/10.3389/fmolb.2021.593310
work_keys_str_mv AT zoumingli thesmaddependenttgfbandbmpsignalingpathwayinboneremodelingandtherapies
AT chenzhonghua thesmaddependenttgfbandbmpsignalingpathwayinboneremodelingandtherapies
AT tengyingying thesmaddependenttgfbandbmpsignalingpathwayinboneremodelingandtherapies
AT liusiyu thesmaddependenttgfbandbmpsignalingpathwayinboneremodelingandtherapies
AT jiayuan thesmaddependenttgfbandbmpsignalingpathwayinboneremodelingandtherapies
AT zhangkaiwen thesmaddependenttgfbandbmpsignalingpathwayinboneremodelingandtherapies
AT sunzili thesmaddependenttgfbandbmpsignalingpathwayinboneremodelingandtherapies
AT wujunjie thesmaddependenttgfbandbmpsignalingpathwayinboneremodelingandtherapies
AT yuanzhengdong thesmaddependenttgfbandbmpsignalingpathwayinboneremodelingandtherapies
AT fengyi thesmaddependenttgfbandbmpsignalingpathwayinboneremodelingandtherapies
AT lixia thesmaddependenttgfbandbmpsignalingpathwayinboneremodelingandtherapies
AT xuruisheng thesmaddependenttgfbandbmpsignalingpathwayinboneremodelingandtherapies
AT yuanfenglai thesmaddependenttgfbandbmpsignalingpathwayinboneremodelingandtherapies
AT zoumingli smaddependenttgfbandbmpsignalingpathwayinboneremodelingandtherapies
AT chenzhonghua smaddependenttgfbandbmpsignalingpathwayinboneremodelingandtherapies
AT tengyingying smaddependenttgfbandbmpsignalingpathwayinboneremodelingandtherapies
AT liusiyu smaddependenttgfbandbmpsignalingpathwayinboneremodelingandtherapies
AT jiayuan smaddependenttgfbandbmpsignalingpathwayinboneremodelingandtherapies
AT zhangkaiwen smaddependenttgfbandbmpsignalingpathwayinboneremodelingandtherapies
AT sunzili smaddependenttgfbandbmpsignalingpathwayinboneremodelingandtherapies
AT wujunjie smaddependenttgfbandbmpsignalingpathwayinboneremodelingandtherapies
AT yuanzhengdong smaddependenttgfbandbmpsignalingpathwayinboneremodelingandtherapies
AT fengyi smaddependenttgfbandbmpsignalingpathwayinboneremodelingandtherapies
AT lixia smaddependenttgfbandbmpsignalingpathwayinboneremodelingandtherapies
AT xuruisheng smaddependenttgfbandbmpsignalingpathwayinboneremodelingandtherapies
AT yuanfenglai smaddependenttgfbandbmpsignalingpathwayinboneremodelingandtherapies