Epigenetics and Inflammation in Diabetic Nephropathy

Diabetic nephropathy (DN) leads to high morbidity and disability. Inflammation plays a critical role in the pathogenesis of DN, which involves renal cells and immune cells, the microenvironment, as well as extrinsic factors, such as hyperglycemia, chemokines, cytokines, and growth factors. Epigeneti...

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Autores principales: Shao, Bao-Yi, Zhang, Shao-Fei, Li, Hai-Di, Meng, Xiao-Ming, Chen, Hai-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131683/
https://www.ncbi.nlm.nih.gov/pubmed/34025445
http://dx.doi.org/10.3389/fphys.2021.649587
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author Shao, Bao-Yi
Zhang, Shao-Fei
Li, Hai-Di
Meng, Xiao-Ming
Chen, Hai-Yong
author_facet Shao, Bao-Yi
Zhang, Shao-Fei
Li, Hai-Di
Meng, Xiao-Ming
Chen, Hai-Yong
author_sort Shao, Bao-Yi
collection PubMed
description Diabetic nephropathy (DN) leads to high morbidity and disability. Inflammation plays a critical role in the pathogenesis of DN, which involves renal cells and immune cells, the microenvironment, as well as extrinsic factors, such as hyperglycemia, chemokines, cytokines, and growth factors. Epigenetic modifications usually regulate gene expression via DNA methylation, histone modification, and non-coding RNAs without altering the DNA sequence. During the past years, numerous studies have been published to reveal the mechanisms of epigenetic modifications that regulate inflammation in DN. This review aimed to summarize the latest evidence on the interplay of epigenetics and inflammation in DN, and highlight the potential targets for treatment and diagnosis of DN.
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spelling pubmed-81316832021-05-20 Epigenetics and Inflammation in Diabetic Nephropathy Shao, Bao-Yi Zhang, Shao-Fei Li, Hai-Di Meng, Xiao-Ming Chen, Hai-Yong Front Physiol Physiology Diabetic nephropathy (DN) leads to high morbidity and disability. Inflammation plays a critical role in the pathogenesis of DN, which involves renal cells and immune cells, the microenvironment, as well as extrinsic factors, such as hyperglycemia, chemokines, cytokines, and growth factors. Epigenetic modifications usually regulate gene expression via DNA methylation, histone modification, and non-coding RNAs without altering the DNA sequence. During the past years, numerous studies have been published to reveal the mechanisms of epigenetic modifications that regulate inflammation in DN. This review aimed to summarize the latest evidence on the interplay of epigenetics and inflammation in DN, and highlight the potential targets for treatment and diagnosis of DN. Frontiers Media S.A. 2021-05-05 /pmc/articles/PMC8131683/ /pubmed/34025445 http://dx.doi.org/10.3389/fphys.2021.649587 Text en Copyright © 2021 Shao, Zhang, Li, Meng and Chen. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Shao, Bao-Yi
Zhang, Shao-Fei
Li, Hai-Di
Meng, Xiao-Ming
Chen, Hai-Yong
Epigenetics and Inflammation in Diabetic Nephropathy
title Epigenetics and Inflammation in Diabetic Nephropathy
title_full Epigenetics and Inflammation in Diabetic Nephropathy
title_fullStr Epigenetics and Inflammation in Diabetic Nephropathy
title_full_unstemmed Epigenetics and Inflammation in Diabetic Nephropathy
title_short Epigenetics and Inflammation in Diabetic Nephropathy
title_sort epigenetics and inflammation in diabetic nephropathy
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131683/
https://www.ncbi.nlm.nih.gov/pubmed/34025445
http://dx.doi.org/10.3389/fphys.2021.649587
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AT chenhaiyong epigeneticsandinflammationindiabeticnephropathy

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