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Diagnostic performance and characteristics of anterior nasal collection for the SARS-CoV-2 antigen test: a prospective study

The clinical utility of antigen test using anterior nasal samples has not been well evaluated. We conducted a prospective study in a drive-through testing site located at a PCR center to evaluate the diagnostic performance of the antigen test QuickNavi-COVID19 Ag using anterior nasal samples and to...

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Autores principales: Takeuchi, Yuto, Akashi, Yusaku, Kato, Daisuke, Kuwahara, Miwa, Muramatsu, Shino, Ueda, Atsuo, Notake, Shigeyuki, Nakamura, Koji, Ishikawa, Hiroichi, Suzuki, Hiromichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131686/
https://www.ncbi.nlm.nih.gov/pubmed/34006975
http://dx.doi.org/10.1038/s41598-021-90026-8
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author Takeuchi, Yuto
Akashi, Yusaku
Kato, Daisuke
Kuwahara, Miwa
Muramatsu, Shino
Ueda, Atsuo
Notake, Shigeyuki
Nakamura, Koji
Ishikawa, Hiroichi
Suzuki, Hiromichi
author_facet Takeuchi, Yuto
Akashi, Yusaku
Kato, Daisuke
Kuwahara, Miwa
Muramatsu, Shino
Ueda, Atsuo
Notake, Shigeyuki
Nakamura, Koji
Ishikawa, Hiroichi
Suzuki, Hiromichi
author_sort Takeuchi, Yuto
collection PubMed
description The clinical utility of antigen test using anterior nasal samples has not been well evaluated. We conducted a prospective study in a drive-through testing site located at a PCR center to evaluate the diagnostic performance of the antigen test QuickNavi-COVID19 Ag using anterior nasal samples and to compare the degrees of coughs or sneezes induction and the severity of pain between anterior nasal collection and nasopharyngeal collection. The study included a total of 862 participants, of which 91.6% were symptomatic. The median duration from symptom onset to sample collection was 2.0 days. Fifty-one participants tested positive for severe acute respiratory syndrome coronavirus 2 on reverse transcription PCR (RT-PCR) with nasopharyngeal samples, and all of them were symptomatic. In comparison to the findings of RT-PCR, the antigen test using anterior nasal samples showed 72.5% sensitivity (95% confidence interval [CI] 58.3–84.1%) and 100% specificity (95% CI 99.3–100%). Anterior nasal collection was associated with a significantly lower degree of coughs or sneezes induction and the severity of pain in comparison to nasopharyngeal collection (p < 0.001). The antigen test using anterior nasal samples showed moderate sensitivity in symptomatic patients who were at the early stages of the disease course but was less painful and induced fewer coughs or sneezes.
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spelling pubmed-81316862021-05-25 Diagnostic performance and characteristics of anterior nasal collection for the SARS-CoV-2 antigen test: a prospective study Takeuchi, Yuto Akashi, Yusaku Kato, Daisuke Kuwahara, Miwa Muramatsu, Shino Ueda, Atsuo Notake, Shigeyuki Nakamura, Koji Ishikawa, Hiroichi Suzuki, Hiromichi Sci Rep Article The clinical utility of antigen test using anterior nasal samples has not been well evaluated. We conducted a prospective study in a drive-through testing site located at a PCR center to evaluate the diagnostic performance of the antigen test QuickNavi-COVID19 Ag using anterior nasal samples and to compare the degrees of coughs or sneezes induction and the severity of pain between anterior nasal collection and nasopharyngeal collection. The study included a total of 862 participants, of which 91.6% were symptomatic. The median duration from symptom onset to sample collection was 2.0 days. Fifty-one participants tested positive for severe acute respiratory syndrome coronavirus 2 on reverse transcription PCR (RT-PCR) with nasopharyngeal samples, and all of them were symptomatic. In comparison to the findings of RT-PCR, the antigen test using anterior nasal samples showed 72.5% sensitivity (95% confidence interval [CI] 58.3–84.1%) and 100% specificity (95% CI 99.3–100%). Anterior nasal collection was associated with a significantly lower degree of coughs or sneezes induction and the severity of pain in comparison to nasopharyngeal collection (p < 0.001). The antigen test using anterior nasal samples showed moderate sensitivity in symptomatic patients who were at the early stages of the disease course but was less painful and induced fewer coughs or sneezes. Nature Publishing Group UK 2021-05-18 /pmc/articles/PMC8131686/ /pubmed/34006975 http://dx.doi.org/10.1038/s41598-021-90026-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Takeuchi, Yuto
Akashi, Yusaku
Kato, Daisuke
Kuwahara, Miwa
Muramatsu, Shino
Ueda, Atsuo
Notake, Shigeyuki
Nakamura, Koji
Ishikawa, Hiroichi
Suzuki, Hiromichi
Diagnostic performance and characteristics of anterior nasal collection for the SARS-CoV-2 antigen test: a prospective study
title Diagnostic performance and characteristics of anterior nasal collection for the SARS-CoV-2 antigen test: a prospective study
title_full Diagnostic performance and characteristics of anterior nasal collection for the SARS-CoV-2 antigen test: a prospective study
title_fullStr Diagnostic performance and characteristics of anterior nasal collection for the SARS-CoV-2 antigen test: a prospective study
title_full_unstemmed Diagnostic performance and characteristics of anterior nasal collection for the SARS-CoV-2 antigen test: a prospective study
title_short Diagnostic performance and characteristics of anterior nasal collection for the SARS-CoV-2 antigen test: a prospective study
title_sort diagnostic performance and characteristics of anterior nasal collection for the sars-cov-2 antigen test: a prospective study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131686/
https://www.ncbi.nlm.nih.gov/pubmed/34006975
http://dx.doi.org/10.1038/s41598-021-90026-8
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