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Iron aggravates hepatic insulin resistance in the absence of inflammation in a novel db/db mouse model with iron overload

OBJECTIVE: The molecular pathogenesis of late complications associated with type 2 diabetes mellitus (T2DM) is not yet fully understood. While high glucose levels indicated by increased HbA1c only poorly explain disease progression and late complications, a pro-inflammatory status, oxidative stress,...

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Detalles Bibliográficos
Autores principales: Altamura, Sandro, Müdder, Katja, Schlotterer, Andrea, Fleming, Thomas, Heidenreich, Elena, Qiu, Ruiyue, Hammes, Hans-Peter, Nawroth, Peter, Muckenthaler, Martina U.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131719/
https://www.ncbi.nlm.nih.gov/pubmed/33872860
http://dx.doi.org/10.1016/j.molmet.2021.101235