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IL-4 inhibits regulatory T cells differentiation by HDAC9-mediated epigenetic regulation
Regulatory T cells play a crucial role in orchestrating immune response and maintaining immune tolerance, and the expression of the Foxp3 gene is indispensable to the differentiation of regulatory T cells. IL-4 shows strong inhibitory effects on Foxp3 expression and regulatory T cells differentiatio...
Autores principales: | Cui, Jikai, Xu, Heng, Yu, Jizhang, Li, Yuan, Chen, Zhang, Zou, Yanqiang, Zhang, Xi, Du, Yifan, Xia, Jiahong, Wu, Jie |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131756/ https://www.ncbi.nlm.nih.gov/pubmed/34006836 http://dx.doi.org/10.1038/s41419-021-03769-7 |
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