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Insulin receptor substrate 1, but not IRS2, plays a dominant role in regulating pancreatic alpha cell function in mice

Dysregulated glucagon secretion deteriorates glycemic control in type 1 and type 2 diabetes. Although insulin is known to regulate glucagon secretion via its cognate receptor (insulin receptor, INSR) in pancreatic alpha cells, the role of downstream proteins and signaling pathways underlying insulin...

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Detalles Bibliográficos
Autores principales:	Takatani, Tomozumi, Shirakawa, Jun, Shibue, Kimitaka, Gupta, Manoj K., Kim, Hyunki, Lu, Shusheng, Hu, Jiang, White, Morris F., Kennedy, Robert T., Kulkarni, Rohit N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131928/ https://www.ncbi.nlm.nih.gov/pubmed/33839150 http://dx.doi.org/10.1016/j.jbc.2021.100646

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