Comparison of the pH- and thermally-induced fluctuations of a therapeutic antibody Fab fragment by molecular dynamics simulation

Successful development of protein therapeutics depends critically on achieving stability under a range of conditions. A deeper understanding of the drivers of instability across different stress conditions, will enable the engineering of more robust protein scaffolds. We compared the impacts of low...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Cheng, Codina, Nuria, Tang, Jiazhi, Yu, Haoran, Chakroun, Nesrine, Kozielski, Frank, Dalby, Paul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131956/
https://www.ncbi.nlm.nih.gov/pubmed/34093988
http://dx.doi.org/10.1016/j.csbj.2021.05.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131956/
https://www.ncbi.nlm.nih.gov/pubmed/34093988
http://dx.doi.org/10.1016/j.csbj.2021.05.005

Ejemplares similares