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Arginine substitution by alanine at the P1 position increases the selectivity of CmPI-II, a non-classical Kazal inhibitor

CmPI-II is a Kazal-type tight-binding inhibitor isolated from the Caribbean snail Cenchritis muricatus. This inhibitor has an unusual specificity in the Kazal family, as it can inhibit subtilisin A (SUBTA), elastases and trypsin. An alanine in CmPI-II P1 site could avoid trypsin inhibition while imp...

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Detalles Bibliográficos
Autores principales:	Rojas, Laritza, Cabrera-Muñoz, Aymara, Gil Pradas, Dayrom, González, Jessica B., Alonso-del-Rivero, Maday, González-González, Yamile
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8131977/ https://www.ncbi.nlm.nih.gov/pubmed/34027134 http://dx.doi.org/10.1016/j.bbrep.2021.101008

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