A Combined Model of Human iPSC‐Derived Liver Organoids and Hepatocytes Reveals Ferroptosis in DGUOK Mutant mtDNA Depletion Syndrome

Mitochondrial DNA depletion syndrome (MDS) is a group of severe inherited disorders caused by mutations in genes, such as deoxyribonucleoside kinase (DGUOK). A great majority of DGUOK mutant MDS patients develop iron overload progressing to severe liver failure. However, the pathological mechanisms...

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Detalles Bibliográficos
Autores principales: Guo, Jingyi, Duan, Lifan, He, Xueying, Li, Shengbiao, Wu, Yi, Xiang, Ge, Bao, Feixiang, Yang, Liang, Shi, Hongyan, Gao, Mi, Zheng, Lingjun, Hu, Huili, Liu, Xingguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8132052/
https://www.ncbi.nlm.nih.gov/pubmed/34026460
http://dx.doi.org/10.1002/advs.202004680

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