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An Insulin‐Inspired Supramolecular Hydrogel for Prevention of Type 1 Diabetes
Supramolecular peptide hydrogel has shown promising potential in vaccine development largely because of its ability to function both as antigen depot and immune adjuvant. Nap‐G(d)F(d)F(d)Y, a tetrapeptide hydrogel that has been previously reported to exhibit adjuvant effect, is inadvertently found t...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8132061/ https://www.ncbi.nlm.nih.gov/pubmed/34026440 http://dx.doi.org/10.1002/advs.202003599 |
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author | Liu, Mohan Wang, Zhongyan Feng, Dandan Shang, Yuna Li, Xinxin Liu, Jianfeng Li, Chen Yang, Zhimou |
author_facet | Liu, Mohan Wang, Zhongyan Feng, Dandan Shang, Yuna Li, Xinxin Liu, Jianfeng Li, Chen Yang, Zhimou |
author_sort | Liu, Mohan |
collection | PubMed |
description | Supramolecular peptide hydrogel has shown promising potential in vaccine development largely because of its ability to function both as antigen depot and immune adjuvant. Nap‐G(d)F(d)F(d)Y, a tetrapeptide hydrogel that has been previously reported to exhibit adjuvant effect, is inadvertently found to contain conserved peptide sequence for insulin, proinsulin, and glutamic acid decarboxylase, 3 major autoantigens for the autoimmune type 1 diabetes (T1D). At present, despite being managed clinically with insulin replacement therapy, T1D remains a major health threat with rapidly increasing incidences, especially in children and young adults, and antigen‐specific immune tolerance induction has been proposed as a feasible approach to prevent or delay T1D progression at an early stage. Here, it is reported that innoculation of Nap‐G(d)F(d)F(d)Y leads to complete protection of nonobese diabetic (NOD) mice from T1D development till the age of 36 weeks. Better maintenance of pancreatic islet morphology with minimal immune cell infiltration is also observed from mice exposed to Nap‐G(d)F(d)F(d)Y. This beneficial impact is mainly due to its facilitative role on enhancing peripheral T regulatory cell (Treg) population, shown as increased splenic Treg percentage, and function, demonstrated by maintenance of circulating TGF‐β1 level. Serum cytokine microarray data further implicate a “buffering” role of Nap‐G(d)F(d)F(d)Y on systemic inflammatory tone in NOD mice. Thus, with its versatility, applicability, and excellent potency, Nap‐G(d)F(d)F(d)Y is posited as a novel therapeutic intervention for T1D. |
format | Online Article Text |
id | pubmed-8132061 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-81320612021-05-21 An Insulin‐Inspired Supramolecular Hydrogel for Prevention of Type 1 Diabetes Liu, Mohan Wang, Zhongyan Feng, Dandan Shang, Yuna Li, Xinxin Liu, Jianfeng Li, Chen Yang, Zhimou Adv Sci (Weinh) Full Papers Supramolecular peptide hydrogel has shown promising potential in vaccine development largely because of its ability to function both as antigen depot and immune adjuvant. Nap‐G(d)F(d)F(d)Y, a tetrapeptide hydrogel that has been previously reported to exhibit adjuvant effect, is inadvertently found to contain conserved peptide sequence for insulin, proinsulin, and glutamic acid decarboxylase, 3 major autoantigens for the autoimmune type 1 diabetes (T1D). At present, despite being managed clinically with insulin replacement therapy, T1D remains a major health threat with rapidly increasing incidences, especially in children and young adults, and antigen‐specific immune tolerance induction has been proposed as a feasible approach to prevent or delay T1D progression at an early stage. Here, it is reported that innoculation of Nap‐G(d)F(d)F(d)Y leads to complete protection of nonobese diabetic (NOD) mice from T1D development till the age of 36 weeks. Better maintenance of pancreatic islet morphology with minimal immune cell infiltration is also observed from mice exposed to Nap‐G(d)F(d)F(d)Y. This beneficial impact is mainly due to its facilitative role on enhancing peripheral T regulatory cell (Treg) population, shown as increased splenic Treg percentage, and function, demonstrated by maintenance of circulating TGF‐β1 level. Serum cytokine microarray data further implicate a “buffering” role of Nap‐G(d)F(d)F(d)Y on systemic inflammatory tone in NOD mice. Thus, with its versatility, applicability, and excellent potency, Nap‐G(d)F(d)F(d)Y is posited as a novel therapeutic intervention for T1D. John Wiley and Sons Inc. 2021-04-09 /pmc/articles/PMC8132061/ /pubmed/34026440 http://dx.doi.org/10.1002/advs.202003599 Text en © 2021 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Full Papers Liu, Mohan Wang, Zhongyan Feng, Dandan Shang, Yuna Li, Xinxin Liu, Jianfeng Li, Chen Yang, Zhimou An Insulin‐Inspired Supramolecular Hydrogel for Prevention of Type 1 Diabetes |
title | An Insulin‐Inspired Supramolecular Hydrogel for Prevention of Type 1 Diabetes |
title_full | An Insulin‐Inspired Supramolecular Hydrogel for Prevention of Type 1 Diabetes |
title_fullStr | An Insulin‐Inspired Supramolecular Hydrogel for Prevention of Type 1 Diabetes |
title_full_unstemmed | An Insulin‐Inspired Supramolecular Hydrogel for Prevention of Type 1 Diabetes |
title_short | An Insulin‐Inspired Supramolecular Hydrogel for Prevention of Type 1 Diabetes |
title_sort | insulin‐inspired supramolecular hydrogel for prevention of type 1 diabetes |
topic | Full Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8132061/ https://www.ncbi.nlm.nih.gov/pubmed/34026440 http://dx.doi.org/10.1002/advs.202003599 |
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