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Bio‐Inspired Multi‐Mode Pain‐Perceptual System (MMPPS) with Noxious Stimuli Warning, Damage Localization, and Enhanced Damage Protection

The multi‐mode pain‐perceptual system (MMPPS) is essential for the human body to perceive noxious stimuli in all circumstances and make an appropriate reaction. Based on the central sensitization mechanism, the MMPPS can switch between different working modes and thus offers a smarter protection mec...

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Autores principales: Li, Fali, Gao, Shuang, Lu, Ying, Asghar, Waqas, Cao, Jinwei, Hu, Chao, Yang, Huali, Wu, Yuanzhao, Li, Shengbin, Shang, Jie, Liao, Meiyong, Liu, Yiwei, Li, Run‐Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8132158/
https://www.ncbi.nlm.nih.gov/pubmed/34026450
http://dx.doi.org/10.1002/advs.202004208
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author Li, Fali
Gao, Shuang
Lu, Ying
Asghar, Waqas
Cao, Jinwei
Hu, Chao
Yang, Huali
Wu, Yuanzhao
Li, Shengbin
Shang, Jie
Liao, Meiyong
Liu, Yiwei
Li, Run‐Wei
author_facet Li, Fali
Gao, Shuang
Lu, Ying
Asghar, Waqas
Cao, Jinwei
Hu, Chao
Yang, Huali
Wu, Yuanzhao
Li, Shengbin
Shang, Jie
Liao, Meiyong
Liu, Yiwei
Li, Run‐Wei
author_sort Li, Fali
collection PubMed
description The multi‐mode pain‐perceptual system (MMPPS) is essential for the human body to perceive noxious stimuli in all circumstances and make an appropriate reaction. Based on the central sensitization mechanism, the MMPPS can switch between different working modes and thus offers a smarter protection mechanism to human body. Accordingly, before injury MMPPS can offer warning of excessive pressure with normal pressure threshold. After injury, extra care on the periphery of damage will be activated by decreasing the pressure threshold. Furthermore, the MMPPS will gradually recover back to a normal state as damage heals. Although current devices can realize basic functions like damage localization and nociceptor signal imitating, the development of a human‐like MMPPS is still a great challenge. Here, a bio‐inspired MMPPS is developed for prosthetics protection, in which all working modes is realized and controlled by mimicking the central sensitization mechanism. Accordingly, the system warns one of a potential injury, identifies the damaged area, and subsequently offers extra care. The proposed system can open new avenues for designing next‐generation prosthetics, especially make other smart sensing systems operate under complete protection against injuries.
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spelling pubmed-81321582021-05-21 Bio‐Inspired Multi‐Mode Pain‐Perceptual System (MMPPS) with Noxious Stimuli Warning, Damage Localization, and Enhanced Damage Protection Li, Fali Gao, Shuang Lu, Ying Asghar, Waqas Cao, Jinwei Hu, Chao Yang, Huali Wu, Yuanzhao Li, Shengbin Shang, Jie Liao, Meiyong Liu, Yiwei Li, Run‐Wei Adv Sci (Weinh) Full Papers The multi‐mode pain‐perceptual system (MMPPS) is essential for the human body to perceive noxious stimuli in all circumstances and make an appropriate reaction. Based on the central sensitization mechanism, the MMPPS can switch between different working modes and thus offers a smarter protection mechanism to human body. Accordingly, before injury MMPPS can offer warning of excessive pressure with normal pressure threshold. After injury, extra care on the periphery of damage will be activated by decreasing the pressure threshold. Furthermore, the MMPPS will gradually recover back to a normal state as damage heals. Although current devices can realize basic functions like damage localization and nociceptor signal imitating, the development of a human‐like MMPPS is still a great challenge. Here, a bio‐inspired MMPPS is developed for prosthetics protection, in which all working modes is realized and controlled by mimicking the central sensitization mechanism. Accordingly, the system warns one of a potential injury, identifies the damaged area, and subsequently offers extra care. The proposed system can open new avenues for designing next‐generation prosthetics, especially make other smart sensing systems operate under complete protection against injuries. John Wiley and Sons Inc. 2021-03-08 /pmc/articles/PMC8132158/ /pubmed/34026450 http://dx.doi.org/10.1002/advs.202004208 Text en © 2021 The Authors. Advanced Science published by Wiley‐VCH GmbH https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Full Papers
Li, Fali
Gao, Shuang
Lu, Ying
Asghar, Waqas
Cao, Jinwei
Hu, Chao
Yang, Huali
Wu, Yuanzhao
Li, Shengbin
Shang, Jie
Liao, Meiyong
Liu, Yiwei
Li, Run‐Wei
Bio‐Inspired Multi‐Mode Pain‐Perceptual System (MMPPS) with Noxious Stimuli Warning, Damage Localization, and Enhanced Damage Protection
title Bio‐Inspired Multi‐Mode Pain‐Perceptual System (MMPPS) with Noxious Stimuli Warning, Damage Localization, and Enhanced Damage Protection
title_full Bio‐Inspired Multi‐Mode Pain‐Perceptual System (MMPPS) with Noxious Stimuli Warning, Damage Localization, and Enhanced Damage Protection
title_fullStr Bio‐Inspired Multi‐Mode Pain‐Perceptual System (MMPPS) with Noxious Stimuli Warning, Damage Localization, and Enhanced Damage Protection
title_full_unstemmed Bio‐Inspired Multi‐Mode Pain‐Perceptual System (MMPPS) with Noxious Stimuli Warning, Damage Localization, and Enhanced Damage Protection
title_short Bio‐Inspired Multi‐Mode Pain‐Perceptual System (MMPPS) with Noxious Stimuli Warning, Damage Localization, and Enhanced Damage Protection
title_sort bio‐inspired multi‐mode pain‐perceptual system (mmpps) with noxious stimuli warning, damage localization, and enhanced damage protection
topic Full Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8132158/
https://www.ncbi.nlm.nih.gov/pubmed/34026450
http://dx.doi.org/10.1002/advs.202004208
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