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Impact of comorbidities on COVID-19 outcome

BACKGROUND AND AIMS: The coronavirus disease 19 (COVID-19) pandemic has spread rapidly around the globe with considerable morbidity and mortality. Coexistence of comorbidities with COVID-19 have consistently been reported as risk factors for unfavorable prognosis. We aim at this study to evaluate th...

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Autores principales: khedr, Eman M, Daef, Enas, Mohamed-Hussein, Aliae, Mostafa, Ehab F, zein, Mohamed, Hassany, Sahar M, Galal, Hanan, Hassan, Shimaa Abbas, Galal, Islam, Zarzour, Amro A., Hetta, Helal F, Hassan, Hebatallah M., Amin, Mariam Taher, Hashem, Maiada k
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8132266/
https://www.ncbi.nlm.nih.gov/pubmed/34013292
http://dx.doi.org/10.1101/2020.11.28.20240267
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author khedr, Eman M
Daef, Enas
Mohamed-Hussein, Aliae
Mostafa, Ehab F
zein, Mohamed
Hassany, Sahar M
Galal, Hanan
Hassan, Shimaa Abbas
Galal, Islam
Zarzour, Amro A.
Hetta, Helal F
Hassan, Hebatallah M.
Amin, Mariam Taher
Hashem, Maiada k
author_facet khedr, Eman M
Daef, Enas
Mohamed-Hussein, Aliae
Mostafa, Ehab F
zein, Mohamed
Hassany, Sahar M
Galal, Hanan
Hassan, Shimaa Abbas
Galal, Islam
Zarzour, Amro A.
Hetta, Helal F
Hassan, Hebatallah M.
Amin, Mariam Taher
Hashem, Maiada k
author_sort khedr, Eman M
collection PubMed
description BACKGROUND AND AIMS: The coronavirus disease 19 (COVID-19) pandemic has spread rapidly around the globe with considerable morbidity and mortality. Coexistence of comorbidities with COVID-19 have consistently been reported as risk factors for unfavorable prognosis. We aim at this study to evaluate the impact of comorbidities in COVID-19 patients on the outcome and determine predictors of prolonged hospital stay, requisite for ICU admission or decease. METHODS: Four hundreds and thirty nine adult patients who are admitted through (June and July 2020) in Assiut and Aswan University Hospitals were included in the study. All participants were diagnosed with COVID-19 according to Egyptian Ministry of Health guidance as definite case or Probable case. Detection of SARS-CoV-2 RNA was done by (TaqManâ„¢ 2019-nCoV Control Kit v1 (Cat. No. A47532) supplied by QIAGEN, Germany on the Applied Biosystem 7500 Fast RT PCR System, USA. RESULTS: Patients with comorbidities represented 61.7% of all cases. Constitutional symptoms especially myalgia and LRT symptoms such as dyspnea were significantly higher in patients with comorbidities (P < 0.05). Patients with comorbidities had significantly worse laboratory parameters. ICU admission was higher in patients with comorbidities (35.8%). Among different comorbidities 45.4% of CVD cases were admitted in ICU followed by DM cases (40.8%). Also, patients with comorbidities needed invasive mechanical ventilation more than those without comorbidity (31 vs. 10.7%, P<0.001). Significant lower frequency of recovery was found in COVID-19 patients with comorbidities (59% vs. 81%, P<0.001) and death rate was significantly higher in cases with comorbidities (P< 0.001). The survival rates in cases with pre-existing CVD and neurological diseases were lower than those without disease (P<0.002 and 0.001 respectively). CONCLUSION: Association of cardiovascular comorbid conditions including hypertension or neurological diseases together with COVID-19 infections carries higher risks of mortality. However, other comorbidities such as diabetes mellitus, chronic pulmonary or kidney diseases may also contribute to increased COVID-19 severity.
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spelling pubmed-81322662021-05-20 Impact of comorbidities on COVID-19 outcome khedr, Eman M Daef, Enas Mohamed-Hussein, Aliae Mostafa, Ehab F zein, Mohamed Hassany, Sahar M Galal, Hanan Hassan, Shimaa Abbas Galal, Islam Zarzour, Amro A. Hetta, Helal F Hassan, Hebatallah M. Amin, Mariam Taher Hashem, Maiada k medRxiv Article BACKGROUND AND AIMS: The coronavirus disease 19 (COVID-19) pandemic has spread rapidly around the globe with considerable morbidity and mortality. Coexistence of comorbidities with COVID-19 have consistently been reported as risk factors for unfavorable prognosis. We aim at this study to evaluate the impact of comorbidities in COVID-19 patients on the outcome and determine predictors of prolonged hospital stay, requisite for ICU admission or decease. METHODS: Four hundreds and thirty nine adult patients who are admitted through (June and July 2020) in Assiut and Aswan University Hospitals were included in the study. All participants were diagnosed with COVID-19 according to Egyptian Ministry of Health guidance as definite case or Probable case. Detection of SARS-CoV-2 RNA was done by (TaqManâ„¢ 2019-nCoV Control Kit v1 (Cat. No. A47532) supplied by QIAGEN, Germany on the Applied Biosystem 7500 Fast RT PCR System, USA. RESULTS: Patients with comorbidities represented 61.7% of all cases. Constitutional symptoms especially myalgia and LRT symptoms such as dyspnea were significantly higher in patients with comorbidities (P < 0.05). Patients with comorbidities had significantly worse laboratory parameters. ICU admission was higher in patients with comorbidities (35.8%). Among different comorbidities 45.4% of CVD cases were admitted in ICU followed by DM cases (40.8%). Also, patients with comorbidities needed invasive mechanical ventilation more than those without comorbidity (31 vs. 10.7%, P<0.001). Significant lower frequency of recovery was found in COVID-19 patients with comorbidities (59% vs. 81%, P<0.001) and death rate was significantly higher in cases with comorbidities (P< 0.001). The survival rates in cases with pre-existing CVD and neurological diseases were lower than those without disease (P<0.002 and 0.001 respectively). CONCLUSION: Association of cardiovascular comorbid conditions including hypertension or neurological diseases together with COVID-19 infections carries higher risks of mortality. However, other comorbidities such as diabetes mellitus, chronic pulmonary or kidney diseases may also contribute to increased COVID-19 severity. Cold Spring Harbor Laboratory 2020-11-30 /pmc/articles/PMC8132266/ /pubmed/34013292 http://dx.doi.org/10.1101/2020.11.28.20240267 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
spellingShingle Article
khedr, Eman M
Daef, Enas
Mohamed-Hussein, Aliae
Mostafa, Ehab F
zein, Mohamed
Hassany, Sahar M
Galal, Hanan
Hassan, Shimaa Abbas
Galal, Islam
Zarzour, Amro A.
Hetta, Helal F
Hassan, Hebatallah M.
Amin, Mariam Taher
Hashem, Maiada k
Impact of comorbidities on COVID-19 outcome
title Impact of comorbidities on COVID-19 outcome
title_full Impact of comorbidities on COVID-19 outcome
title_fullStr Impact of comorbidities on COVID-19 outcome
title_full_unstemmed Impact of comorbidities on COVID-19 outcome
title_short Impact of comorbidities on COVID-19 outcome
title_sort impact of comorbidities on covid-19 outcome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8132266/
https://www.ncbi.nlm.nih.gov/pubmed/34013292
http://dx.doi.org/10.1101/2020.11.28.20240267
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