Plasmodium infection induces cross-reactive antibodies to carbohydrate epitopes on the SARS-CoV-2 Spike protein

Individuals with acute malaria infection generated high levels of antibodies that cross-react with the SARS-CoV-2 Spike protein. Cross-reactive antibodies specifically recognized the sialic acid moiety on N-linked glycans of the Spike protein and do not neutralize in vitro SARS-CoV-2. Sero-surveilla...

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Detalles Bibliográficos
Autores principales: Lapidus, Sarah, Liu, Feimei, Casanovas-Massana, Arnau, Dai, Yile, Huck, John D., Lucas, Carolina, Klein, Jon, Filler, Renata B., Strine, Madison S., Sy, Mouhamad, Deme, Awa B., Badiane, Aida S., Dieye, Baba, Ndiaye, Ibrahima Mbaye, Diedhiou, Younous, Mbaye, Amadou Moctar, Diagne, Cheikh Tidiane, Vigan-Womas, Inés, Mbengue, Alassane, Sadio, Bacary D., Diagne, Moussa M., Moore, Adam J., Mangou, Khadidiatou, Diallo, Fatoumata, Sene, Seynabou D., Pouye, Mariama N., Faye, Rokhaya, Diouf, Babacar, Nery, Nivison, Costa, Federico, Reis, Mitermayer, Muenker, M. Catherine, Hodson, Daniel Z., Mbarga, Yannick, Katz, Ben Z., Andrews, Jason R., Campbell, Melissa, Srivathsan, Ariktha, Kamath, Kathy, Baum-Jones, Elisabeth, Faye, Ousmane, Sall, Amadou Alpha, Quintero Vélez, Juan Carlos, Cappello, Michael, Wilson, Michael, Ben-Mamoun, Choukri, Somé, Fabrice A., Dabiré, Roch K., Moukoko, Carole Else Eboumbou, Ouédraogo, Jean Bosco, Boum, Yap, Shon, John, Ndiaye, Daouda, Wisnewski, Adam, Parikh, Sunil, Iwasaki, Akiko, Wilen, Craig B., Ko, Albert I., Ring, Aaron M., Bei, Amy K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8132281/
https://www.ncbi.nlm.nih.gov/pubmed/34013301
http://dx.doi.org/10.1101/2021.05.10.21256855
Descripción
Sumario:Individuals with acute malaria infection generated high levels of antibodies that cross-react with the SARS-CoV-2 Spike protein. Cross-reactive antibodies specifically recognized the sialic acid moiety on N-linked glycans of the Spike protein and do not neutralize in vitro SARS-CoV-2. Sero-surveillance is critical for monitoring and projecting disease burden and risk during the pandemic; however, routine use of Spike protein-based assays may overestimate SARS-CoV-2 exposure and population-level immunity in malaria-endemic countries.

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