GSDMD contributes to host defence against Staphylococcus aureus skin infection by suppressing the Cxcl1–Cxcr2 axis

Gasdermin D (GSDMD), a member of the gasdermin protein family, is a caspase substrate, and its cleavage is required for pyroptosis and IL-1β secretion. To date, the role and regulatory mechanism of GSDMD during cutaneous microbial infection remain unclear. Here, we showed that GSDMD protected agains...

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Detalles Bibliográficos
Autores principales: Liu, Zhen-Zhen, Yang, Yong-Jun, Zhou, Feng-Hua, Ma, Ke, Lin, Xiao-Qi, Yan, Shi-Qing, Gao, Yu, Chen, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8132424/
https://www.ncbi.nlm.nih.gov/pubmed/34011393
http://dx.doi.org/10.1186/s13567-021-00937-7

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