Huntingtin-mediated axonal transport requires arginine methylation by PRMT6

The huntingtin (HTT) protein transports various organelles, including vesicles containing neurotrophic factors, from embryonic development throughout life. To better understand how HTT mediates axonal transport and why this function is disrupted in Huntington’s disease (HD), we study vesicle-associa...

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Detalles Bibliográficos
Autores principales: Migazzi, Alice, Scaramuzzino, Chiara, Anderson, Eric N., Tripathy, Debasmita, Hernández, Ivó H., Grant, Rogan A., Roccuzzo, Michela, Tosatto, Laura, Virlogeux, Amandine, Zuccato, Chiara, Caricasole, Andrea, Ratovitski, Tamara, Ross, Christopher A., Pandey, Udai B., Lucas, José J., Saudou, Frédéric, Pennuto, Maria, Basso, Manuela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8132453/
https://www.ncbi.nlm.nih.gov/pubmed/33852844
http://dx.doi.org/10.1016/j.celrep.2021.108980

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8132453/
https://www.ncbi.nlm.nih.gov/pubmed/33852844
http://dx.doi.org/10.1016/j.celrep.2021.108980

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