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Role of serum C-reactive protein and interleukin-6 as a predictor of intra-abdominal and surgical site infections after elective abdominal surgery

INTRODUCTION: Infections after surgeries considerably increase patients' hospital stay, thereby prolonging patients' early return to productive life. At the same time, the cost of hospitalization also increases. Therefore, if objective tests can predict infections before it actually happen...

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Autores principales: Hajong, Ranendra, Newme, Kewithinwangbo, Nath, Chandan Kr, Moirangthem, Thoiba, Dhal, Malaya Ranjan, Pala, Star
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8132759/
https://www.ncbi.nlm.nih.gov/pubmed/34017761
http://dx.doi.org/10.4103/jfmpc.jfmpc_1191_20
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author Hajong, Ranendra
Newme, Kewithinwangbo
Nath, Chandan Kr
Moirangthem, Thoiba
Dhal, Malaya Ranjan
Pala, Star
author_facet Hajong, Ranendra
Newme, Kewithinwangbo
Nath, Chandan Kr
Moirangthem, Thoiba
Dhal, Malaya Ranjan
Pala, Star
author_sort Hajong, Ranendra
collection PubMed
description INTRODUCTION: Infections after surgeries considerably increase patients' hospital stay, thereby prolonging patients' early return to productive life. At the same time, the cost of hospitalization also increases. Therefore, if objective tests can predict infections before it actually happens, then more preventive measures in the form of upgrading antibiotics can be taken which might prevent patients from developing serious infections and thereby reduce morbidity and mortality of surgery. MATERIAL AND METHODS: It was a prospective cross sectional study to assess the efficacy of acute phase reactants C-reactive protein (CRP) and interleukin 6 (IL 6) in predicting infections in patients undergoing routine general surgical operations. A total of 74 patients were included in the study. Laparoscopic surgical procedures were not included in the study to maintain uniformity in the procedures. Data so collected were analyzed by using SPSS version 22. RESULTS: A total of 27 patients developed wound infections postoperatively. The mean rise in the levels of CRP and IL 6 was higher in those patients who developed postoperative wound infections. The positive predictive value and negative predictive value was found to be better with IL 6 than with CRP. CONCLUSION: It may be concluded that a serial estimation of CRP and IL 6 postoperatively can predict infections and may be utilized routinely in general surgical practice.
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spelling pubmed-81327592021-05-19 Role of serum C-reactive protein and interleukin-6 as a predictor of intra-abdominal and surgical site infections after elective abdominal surgery Hajong, Ranendra Newme, Kewithinwangbo Nath, Chandan Kr Moirangthem, Thoiba Dhal, Malaya Ranjan Pala, Star J Family Med Prim Care Original Article INTRODUCTION: Infections after surgeries considerably increase patients' hospital stay, thereby prolonging patients' early return to productive life. At the same time, the cost of hospitalization also increases. Therefore, if objective tests can predict infections before it actually happens, then more preventive measures in the form of upgrading antibiotics can be taken which might prevent patients from developing serious infections and thereby reduce morbidity and mortality of surgery. MATERIAL AND METHODS: It was a prospective cross sectional study to assess the efficacy of acute phase reactants C-reactive protein (CRP) and interleukin 6 (IL 6) in predicting infections in patients undergoing routine general surgical operations. A total of 74 patients were included in the study. Laparoscopic surgical procedures were not included in the study to maintain uniformity in the procedures. Data so collected were analyzed by using SPSS version 22. RESULTS: A total of 27 patients developed wound infections postoperatively. The mean rise in the levels of CRP and IL 6 was higher in those patients who developed postoperative wound infections. The positive predictive value and negative predictive value was found to be better with IL 6 than with CRP. CONCLUSION: It may be concluded that a serial estimation of CRP and IL 6 postoperatively can predict infections and may be utilized routinely in general surgical practice. Wolters Kluwer - Medknow 2021-01 2021-01-30 /pmc/articles/PMC8132759/ /pubmed/34017761 http://dx.doi.org/10.4103/jfmpc.jfmpc_1191_20 Text en Copyright: © 2021 Journal of Family Medicine and Primary Care https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Hajong, Ranendra
Newme, Kewithinwangbo
Nath, Chandan Kr
Moirangthem, Thoiba
Dhal, Malaya Ranjan
Pala, Star
Role of serum C-reactive protein and interleukin-6 as a predictor of intra-abdominal and surgical site infections after elective abdominal surgery
title Role of serum C-reactive protein and interleukin-6 as a predictor of intra-abdominal and surgical site infections after elective abdominal surgery
title_full Role of serum C-reactive protein and interleukin-6 as a predictor of intra-abdominal and surgical site infections after elective abdominal surgery
title_fullStr Role of serum C-reactive protein and interleukin-6 as a predictor of intra-abdominal and surgical site infections after elective abdominal surgery
title_full_unstemmed Role of serum C-reactive protein and interleukin-6 as a predictor of intra-abdominal and surgical site infections after elective abdominal surgery
title_short Role of serum C-reactive protein and interleukin-6 as a predictor of intra-abdominal and surgical site infections after elective abdominal surgery
title_sort role of serum c-reactive protein and interleukin-6 as a predictor of intra-abdominal and surgical site infections after elective abdominal surgery
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8132759/
https://www.ncbi.nlm.nih.gov/pubmed/34017761
http://dx.doi.org/10.4103/jfmpc.jfmpc_1191_20
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